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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Islam, Mohammad Rafiqul Roh, Yoon-Seok Cho, Ara Kim, Jinho Kim, Jong-Hoon Eo, Seong-kug Lim, Chae-Woong Kim, Bumseok |
| Description | Country affiliation: South Korea Author Affiliation: Islam MR ( Biosafety Research Institute and Laboratory of Pathology, College of Veterinary Medicine, Chonbuk National University, Jeonju 561-756, South Korea.) |
| Abstract | The mycotoxin citrinin can cause mycotoxic nephropathy, cytotoxicity and genotoxicity. To investigate the immune modulatory effects, CTN was orally administered to female BALB/c mice at the dose of 1, 5, or 10 mg/kg body weight for 14 days, and several immunotoxicity tests were performed. The populations of F4/80+ cells and CD19+ cells were significantly decreased in spleen and MLN. In MLN, CD4+, CD8+, and CD4+CD25+Foxp3+ cell populations were increased. CD8+ cells were increased but CD19+ cells were decreased in intra-epithelial, lamina propria and Peyer's patches lymphocytes. In a cell proliferation assay, along with the increased proliferative capacities of ConA-induced splenocytes and MLN cells, IFN-γ production was increased. The expression of TLR 2 was increased in spleen, but TLR 3 expression in MLN was decreased. The level of serum IgM was reduced. Furthermore, apoptosis was induced in spleen, MLN and Peyer's patches and promoted by the change in the ratio of Bax/Bcl-2 activities. Autophagy gene Atg5 and Beclin-1 were up-regulated in spleen. The expressions of IL-1ß, IL-10, and TNF- were inhibited in murine macrophage cells pre-exposed with TLR ligands. These results indicate that CTN has multiple immune modulatory effects in mice that may alter normal functions of immune system. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 10 |
| Volume Number | 50 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Citrinin Toxicity Lymph Nodes Drug Effects Peyer's Patches Spleen Animals Apoptosis Cell Line Administration & Dosage Dose-response Relationship, Drug Female Food Contamination Gene Expression Regulation Immunology Immunoglobulin M Blood Intestine, Small Cytology Macrophages Mice Mice, Inbred Balb C T-lymphocyte Subsets Toll-like Receptor 2 Genetics Metabolism Toll-like Receptor 3 Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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