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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Capucho, Cristina Sette, Rayra de Souza Predes, Fabrícia de Castro Monteiro, Juliana Pigoso, Acácio A. Barbieri, Renata Dolder, Mary Anne Heidi Severi-Aguiar, Grasiela D. C. |
| Spatial Coverage | Brazil |
| Description | Country affiliation: Brazil Author Affiliation: Capucho C ( Programa de Pós-Graduação em Ciências Biomédicas, Centro Universitário Hermínio Ometto, UNIARARAS, Araras, SP, Brazil.) |
| Abstract | Basal generation of reactive oxygen species (ROS) is essential for male reproductive function, whereas high ROS levels may be linked to low quality of sperm and male infertility. The number of antioxidants known to inflict damage is growing, and it will be of interest to study natural products, which may have this activity. Since the epididymis is known to play an important role in providing the microenvironment for sperm maturation and storage of sperm, this study was undertaken to evaluate the morphometric-stereological and functional alterations in the epididymis after chronic treatment with low doses of Brazilian green propolis, which is known for its antioxidant properties. For this purpose, forty-eight adult male Wistar rats were treated with 3, 6 and 10 mg/kg/day of aqueous extract of Brazilian green propolis during 56 days and morphological parameters, sperm production and number of sperm in rat epididymis and oxidative stress levels were analyzed. The results showed higher sperm production and greater epithelium height of the epididymis initial segment and no induction of oxidative stress in treated animals. Further studies are needed to fully understand the effects of propolis on the reproductive system but our results showed that it could alter male reproductive function. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | 11 |
| Volume Number | 50 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-11-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Epididymis Drug Effects Oxidative Stress Propolis Pharmacology Animals Brazil Catalase Metabolism Anatomy & Histology Male Microscopy, Electron, Transmission Organ Size Rats Rats, Wistar Sperm Count Spermatogenesis Thiobarbituric Acid Reactive Substances Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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