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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Heuschmid, Franziska F. Schneider, Steffen Schuster, Paul Lauer, Birthe Van Ravenzwaay, Bennard |
| Description | Country affiliation: Germany Author Affiliation: Heuschmid FF ( Product Safety Department, BASF SE, Ludwigshafen, Germany.) |
| Abstract | Polyethylene glycol-g-polyvinyl alcohol (PEG-PVA) grafted copolymer was evaluated in developmental toxicity studies with Wistar rats and Himalayan rabbits. Pregnant Wistar rats were gavaged with 0 (vehicle control), 100, 300, or 1000 mg PEG-PVA grafted copolymer/kg bw/day from gestation day (GD) 6-15. Pregnant Himalayan rabbits received the same treatment from GD 6 to 19. On GD 20 and 29 for rats and rabbits, respectively, the animals were euthanized and were examined grossly. For each dam, corpora lutea were counted and number and distribution of implantation sites were determined. The fetuses were removed, sexed, weighed, and evaluated for any external, soft tissue, and skeletal findings. No significant findings were found that could be attributed to administration of PEG-PVA grafted copolymer. Under the conditions of these studies, the no-observed-adverse-effect level (NOAEL) for maternal and developmental toxicity in both species was the highest dose tested of 1000 mg/kg bw/day. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Issue Number | Suppl 1 |
| Volume Number | 51 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-07-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Abnormalities, Drug-induced Excipients Toxicity Polyvinyls Animals Dose-response Relationship, Drug Chemistry Female Fetus Drug Effects Administration & Dosage Pregnancy Rabbits Random Allocation Rats Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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