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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sha, BaoYong Gao, Wei Wang, ShuQi Li, Wei Liang, Xuan Xu, Feng Lu, Tian Jian |
| Description | Author Affiliation: Sha B ( Lab of Cell Biology & Translational Medicine, Xi'an Medical University, Xi'an 710021, PR China.) |
| Abstract | Heart diseases, which are related to oxidative stress (OS), negatively affect millions of people from kids to the elderly. Titanium dioxide (TiO2) has widespread applications in our daily life, especially nanoscale TiO2. Compared to the high risk of particulate matter (≤2.5µm) in air to heart disease patients, related research of TiO2 on diseased body is still unknown, which suggest us to explore the potential effects of nanoscale and microscale TiO2 to heart under OS conditions. Here, we used alloxan to induce OS conditions in rat, and investigated the response of heart tissue to TiO2 in healthy and alloxan treated rats. Compared with NMs treatment only, the synergistic interaction between OS conditions and nano-TiO2 significantly reduced the heart-related function indexes, inducing pathological changes of myocardium with significantly increased levels of cardiac troponin I and creatine kinase-MB. In contrast with the void response of micro-TiO2 to heart functions in alloxan treated rats, aggravation of OS conditions might play an important role in cardiac injury after alloxan and nano-TiO2 dual exposure. Our results demonstrated that OS conditions enhanced the adverse effects of nano-TiO2 to heart, suggesting that the use of NMs in stressed conditions (e.g., drug delivery) needs to be carefully monitored. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 58 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-08-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Heart Injuries Chemically Induced Heart Drug Effects Metal Nanoparticles Oxidative Stress Titanium Toxicity Animals Biological Markers Metabolism Microscopy, Electron, Transmission Rats Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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