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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zhu, Haiyan Jia, Yijing Cao, Hongbin Meng, Fanyun Liu, Xinxin |
| Description | Country affiliation: China Author Affiliation: Zhu H ( Beijing Area Major Laboratory of Protection and Utilization of Traditional Chinese Medicine, Beijing 100875, China); Jia Y ( Beijing Area Major Laboratory of Protection and Utilization of Traditional Chinese Medicine, Beijing 100875, China); Cao H ( Beijing Area Major Laboratory of Protection and Utilization of Traditional Chinese Medicine, Beijing 100875, China); Meng F ( Beijing Area Major Laboratory of Protection and Utilization of Traditional Chinese Medicine, Beijing 100875, China); Liu X ( Beijing Area Major Laboratory of Protection and Utilization of Traditional Chinese Medicine, Beijing 100875, China) |
| Abstract | Arsenic, cadmium, lead, chromium and mercury are toxic elements that occur with high frequency in the soil and thus in agricultural products in China. To explore their combined effects, thirty male and thirty female Sprague-Dawley rats were orally exposed to a mixture of these elements at high dose (2.11, 6.47, 72.82, 2.26 and 2.71 mg/kg bw/day), medium dose (1/10 of the high dose) and low dose (1/100 of the high dose) via their drinking water for 90 days. The results revealed that BUN increased in all rats given the high dose, and serum creatinine increased in female rats given the medium dose. Decreased ALP levels in all treated male rats accompanied decreased RBC counts. In the high dose group, serum albumin, globulin and total protein content decreased in male rats, whereas serum ALT levels increased in female rats. Pathological changes were observed in the hepatocytes and renal tubules of all rats given the high dose, and the numbers of spermatogenic cells and sperm significantly decreased in both the epididymides and testes of the rats given the high dose. Abnormalities were observed earlier and more clearly in the males than in the females under combined exposure. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 71 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Complex Mixtures Metals, Heavy Toxicity Animals Body Weight Drug Effects Dose-response Relationship, Drug Female Male Administration & Dosage Organ Size Rats Rats, Sprague-dawley Toxicity Tests, Subchronic Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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