| Content Provider |
World Health Organization (WHO)-Global Index Medicus |
| Author |
Holvoet, Paul Rull, Anna García-Heredia, Anabel López-Sanromà, Sílvia Geeraert, Benjamine Joven, Jorge Camps, Jordi |
| Description |
Author Affiliation: Holvoet P ( Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, Belgium. Electronic address: paul.holvoet@med.kuleuven.be.); Rull A ( Unitat de Recerca Biomèdica (CRB-URB), Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Reus, Spain.); García-Heredia A ( Unitat de Recerca Biomèdica (CRB-URB), Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Reus, Spain.); López-Sanromà S ( Unitat de Recerca Biomèdica (CRB-URB), Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Reus, Spain.); Geeraert B ( Atherosclerosis and Metabolism Unit, Department of Cardiovascular Sciences, Katholieke Universiteit Leuven, Leuven, Belgium.); Joven J ( Unitat de Recerca Biomèdica (CRB-URB), Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Reus, Spain.); Camps J ( Unitat de Recerca Biomèdica (CRB-URB), Hospital Universitari de Sant Joan, Institut d'Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, Reus, Spain.) |
| Abstract |
There is a close interaction between Type 2 Diabetes, obesity and liver disease. We have studied the effects of the two most abundant Stevia-derived steviol glycosides, stevioside and rebaudioside A, and their aglycol derivative steviol on liver steatosis and the hepatic effects of lipotoxicity using a mouse model of obesity and insulin resistance. We treated ob/ob and LDLR-double deficient mice with stevioside (10 mgâ
kg(-1)â
day-1 p.o., n = 8), rebaudioside A (12 mgâ
kg(-1)â
day-1 p.o., n = 8), or steviol (5 mgâ
kg(-1)â
day(-1) p.o., n = 8). We determined their effects on liver steatosis and on the metabolic effects of lipotoxicity by histological analysis, and by combined gene-expression and metabolomic analyses. All compounds attenuated hepatic steatosis. This could be explained by improved glucose metabolism, fat catabolism, bile acid metabolism, and lipid storage and transport. We identified PPARs as important regulators and observed differences in effects on insulin resistance, inflammation and oxidative stress between Stevia-derived compounds. We conclude that Stevia-derived compounds reduce hepatic steatosis to a similar extent, despite differences in effects on glucose and lipid metabolism, and inflammation and oxidative stress. Thus our data show that liver toxicity can be reduced through several pathophysiological changes. Further identification of active metabolites and underlying mechanisms are warranted. |
| File Format |
HTM / HTML |
| ISSN |
02786915 |
| Volume Number |
77 |
| e-ISSN |
18736351 |
| Journal |
Food and Chemical Toxicology |
| Language |
English |
| Publisher |
Elsevier |
| Publisher Date |
2015-03-01 |
| Publisher Place |
Great Britain (UK) |
| Access Restriction |
One Nation One Subscription (ONOS) |
| Subject Keyword |
Discipline Toxicology__semicolon__nutritional Discipline Sciences Fatty Liver Drug Therapy Liver Drug Effects Plant Preparations Pharmacology Stevia Chemistry Transcriptome Amino Acids Metabolism Animals Bile Acids And Salts Disease Models, Animal Diterpenes, Kaurane Glucose Glucosides Glutathione Insulin Resistance Lipid Metabolism Male Metabolomics Mice Mice, Obese Obesity Oxidative Stress Peroxisome Proliferator-activated Receptors Journal Article Research Support, Non-u.s. Gov't |
| Content Type |
Text |
| Resource Type |
Article |
| Subject |
Medicine Toxicology Food Science |
