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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Zeigler, Brandon M. Cameron, Mark Nelson, Keith Bailey, Kristi Weiner, Myra L. Mahadevan, Brinda Thorsrud, Bjorn |
| Spatial Coverage | Michigan |
| Description | Author Affiliation: Zeigler BM ( MPI Research, Mattawan, MI, 49009, USA. Electronic address: Brandon.Zeigler@mpiresearch.com.); Cameron M ( Beckman Coulter, Southfield, MI, 48033, USA.); Nelson K ( MPI Research, Mattawan, MI, 49009, USA.); Bailey K ( MPI Research, Mattawan, MI, 49009, USA.); Weiner ML ( TOXpertise, Princeton, NJ, 08540, USA.); Mahadevan B ( Abbott Laboratories, Columbus, OH, 43219, USA.); Thorsrud B ( Experimur, Chicago, IL, 60609, USA.) |
| Abstract | The preweaning piglet has been found to be a valuable research model for testing ingredients used in infant formula. As part of the safety assessment, the neonates' immune system is an important component that has to be evaluated. In this study three concurrent strategies were developed to assess immune system status. The methods included (1) immunophenotying to assess circulating innate immune cell populations, (2) monitoring of circulating cytokines, particularly in response to a positive control agent, and (3) monitoring of localized gastrointestinal tissue cytokines using immunohistochemistry (IHC), particularly in response to a positive control agent. All assays were validated using white papers and regulatory guidance within a GLP environment. To validate the assays precision, accuracy and sample stability were evaluated as needed using a fit for purpose approach. In addition animals were treated with proinflammtory substances to detect a positive versus negative signal. In conclusion, these three methods were confirmed to be robust assays to evaluate the immune system and GIT-specific immune responses of preweaning piglets. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Volume Number | 84 |
| e-ISSN | 18736351 |
| Journal | Food and Chemical Toxicology |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-10-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Toxicology__semicolon__nutritional Discipline Sciences Immunity, Innate Immunity, Mucosal Models, Immunological Sus Scrofa Immunology Animals Animals, Newborn Biological Markers Blood Metabolism Crosses, Genetic Cytokines Female Flow Cytometry Veterinary Gastrointestinal Tract Cytology Growth & Development Immunohistochemistry Immunophenotyping Male Michigan Mucous Membrane Protein Stability Reproducibility Of Results Toxicity Tests Journal Article Research Support, Non-u.s. Gov't Validation Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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