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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Begas, Elias Tsioutsiouliti, Athanasia Kouvaras, Evangelos Haroutounian, Serkos A. Kasiotis, Konstantinos M. Kouretas, Dimitrios Asprodini, Eftihia |
| Description | Country affiliation: Greece Author Affiliation: Begas E ( Laboratory of Pharmacology, School of Medicine, University of Thessaly, Larissa, Greece.); Tsioutsiouliti A ( Department of Biochemistry-Biotechnology, University of Thessaly, Larissa, Greece.); Kouvaras E ( Laboratory of Pharmacology, School of Medicine, University of Thessaly, Larissa, Greece.); Haroutounian SA ( Department of Nutritional Physiology and Feeding Laboratory, Faculty of Animal Science and Aquaculture, Agricultural University of Athens, Athens, Greece.); Kasiotis KM ( Benaki Phytopathological Institute, Department of Pesticides Control and Phytopharmacy, Laboratory of Pesticides' Toxicology, Athens, Greece.); Kouretas D ( Department of Biochemistry-Biotechnology, University of Thessaly, Larissa, Greece.); Asprodini E ( Laboratory of Pharmacology, School of Medicine, University of Thessaly, Larissa, Greece.) |
| Abstract | Peppermint leaves are widely used for the symptomatic treatment of digestive disorders. Previous studies have shown significant effects of its natural products on human enzyme activity; however, there is no study available concerning the effects of peppermint tea on metabolizing enzymes in humans. Aim of the present study was to investigate the effect of peppermint tea on CYP1A2, CYP2A6, Xanthine Oxidase (XO), N-acetyltranferase-2 (NAT2) and UDP-glucuronosyltransferases-1A1/1A6 (UGT1A1/1A6) activities in healthy subjects. Four males and five females consumed peppermint tea (2 g of dry leaves/200 mL water, twice daily) for six days. CYP1A2, CYP2A6, XO, NAT2 and UGT1A1/1A6 activities were determined before and at the end of the study period, using the following caffeine and paracetamol metabolic ratios: CYP1A2: 17MX/137MX (saliva) and (AFMU+1MU+1MX)/17MU (urine); CYP2A6: 17MU/(17MU + 17MX), XO: 1MU/(1MU+1MX), NAT2, AFMU/(AFMU+1MU+1MX) and UGT1A1/1A6 glucuronidated/total paracetamol, all determined in urine. NAT2 metabolic ratio was significantly reduced following peppermint consumption (0.15 ± 0.13 vs 0.14 ± 0.13; p < 0.05). CYP1A2 urine and saliva indices were reduced, yet not significantly, following peppermint consumption (urine: 3.17 ± 1.08 vs 2.91 ± 0.76, saliva: 0.56 ± 0.12 vs 0.50 ± 0.12; p > 0.05). Peppermint had no influence on CYP2A6, XO and UGT1A1/1A6 indices. Daily ingestion of peppermint tea may alter pharmacokinetics of clinically administered drugs and promote cancer chemoprevention through NAT2 inhibition. |
| File Format | HTM / HTML |
| ISSN | 02786915 |
| Journal | Food and Chemical Toxicology |
| Volume Number | 100 |
| e-ISSN | 18736351 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Medicine Toxicology Food Science |
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