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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Estrera, Anthony L. Miller, Charles C. Lee, Taek-Yeon Shah, Pallav Irani, Adel D. Ganim, Nidal Abdullah, Saad Safi, Hazim J. |
| Description | Country affiliation: United States Author Affiliation: Estrera AL ( Department of Cardiothoracic and Vascular Surgery, The University of Texas at Houston Medical School, Memorial Hermann Heart and Vascular Institute, Houston, TX, USA. anthony.l.estrera@uth.tmc.edu) |
| Abstract | OBJECTIVES: Antegrade cerebral perfusion (ACP) during hypothermic circulatory arrest (HCA) for ascending/transverse arch repair is used for cerebral protection. This study evaluates ACP in combination with retrograde cerebral perfusion (RCP) during extended HCA and compares it to RCP-only. METHODS: Between January 2005 and April 2007, we performed 64 consecutive arch repairs requiring extended HCA (>40 min). RCP-only was used with 34 patients and ACP with brief RCP ('integrated') was used with 30 patients. Mean HCA time was 51 + or - 13 min. Mean RCP-only time was 47 + or - 9.6 min; in the integrated group, mean ACP time was 42 + or - 14.4 min with an added RCP time of 10.8 + or - 7.6 min. For the entire cohort, 95% (61/64) underwent total arch repair, and 67% (43/64) had elephant trunk reconstruction. Variables predictive of mortality and neurological outcomes were analysed prospectively, but technique selection was non-randomised. RESULTS: Preoperative and operative variables did not differ between the RCP-only and the integrated groups except for aortic valve replacement, which was more frequently performed in the integrated group (33% (10/30) vs 12% (4/34), P=0.05), and preoperative renal dysfunction, which was more frequent in the RCP group (26% (9/34) vs 7% (2/30), P=0.04). No significant difference was observed in outcomes between the groups; however, the integrated group had higher mortality, stroke and temporary neurological deficit than RCP-only. CONCLUSIONS: The observed trends in actual outcomes were a cause for concern. ACP combined with a short period of RCP did not provide better outcomes than RCP-only. The use of RCP remains warranted in our experience. |
| File Format | HTM / HTML |
| ISSN | 10107940 |
| e-ISSN | 1873734X |
| Journal | European Journal of Cardio-Thoracic Surgery |
| Issue Number | 3 |
| Volume Number | 38 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2010-09-01 |
| Publisher Place | Germany |
| Access Restriction | Open |
| Subject Keyword | Discipline Cardiology__semicolon__surgery Aorta, Thoracic Surgery Cerebrovascular Circulation Physiology Blood Vessel Prosthesis Implantation Brain Ischemia Prevention & Control Heart Arrest, Induced Heart Valve Prosthesis Implantation Hypothermia, Induced Intraoperative Care Perfusion Retrospective Studies |
| Content Type | Text |
| Resource Type | Article |
| Subject | Pulmonary and Respiratory Medicine Surgery Cardiology and Cardiovascular Medicine |
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