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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pulicharla, Rama Hegde, Krishnamoorthy Brar, Satinder Kaur Surampalli, Rao Y. |
| Description | Country affiliation: Canada Author Affiliation: Pulicharla R ( INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec G1K 9A9, Canada.); Hegde K ( INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec G1K 9A9, Canada.); Brar SK ( INRS-ETE, Université du Québec, 490, Rue de la Couronne, Québec G1K 9A9, Canada. Electronic address: satinder.brar@ete.inrs.ca.); Surampalli RY ( Department of Civil Engineering, University of Nebraska-Lincoln, N104 SEC PO Box 886105, Lincoln, NE 68588-6105, USA.) |
| Abstract | Concern over tetracyclines (TCs) complexation with metals in the environment is growing as a new class of emerging contaminants. TCs exist as a different net charged species depending on their dissociation constants, pH and the surrounding environment. One of the key concerns about TCs is its strong tendency to interact with various metal ions and form metal complexes. Moreover, co-existence of TCs and metals in the environment and their interactions has shown increased antibiotic resistance. Despite extensive research on TCs complexation, investigations on their antibiotic efficiency and pharmacological profile in bacteria have been limited. In addition, the current knowledge on TCs metal complexation, their fate and risk assessment in the environment are inadequate to obtain a clear understanding of their consequences on living systems. This indicates that vital and comprehensive studies on TCs-metal complexation, especially towards growing antibiotic resistance trends are required. This review summarizes the role of TCs metal complexation on the development of antibiotic resistance. Furthermore, impact of metal complexation on degradation, toxicity and the fate of TCs in the environment are discussed and future recommendations have been made. |
| File Format | HTM / HTML |
| ISSN | 02697491 |
| Journal | Environmental Pollution |
| Volume Number | 221 |
| e-ISSN | 18736424 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2017-02-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Environmental Discipline Science Anti-bacterial Agents Chemistry Coordination Complexes Environmental Pollutants Tetracyclines Ions Metals Journal Article Review |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Pollution Medicine Toxicology |
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