NDLI: Sall1 balances self-renewal and differentiation of renal progenitor cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Basta, Jeannine M. Robbins, Lynn Kiefer, Susan M. Dorsett, Dale Rauchman, Michael
Description	Country affiliation: United States Author Affiliation: Basta JM ( Department of Internal Medicine, Saint Louis University, St Louis, MO 63104, USA.)
Abstract	The formation of the proper number of functional nephrons requires a delicate balance between renal progenitor cell self-renewal and differentiation. The molecular factors that regulate the dramatic expansion of the progenitor cell pool and differentiation of these cells into nephron precursor structures (renal vesicles) are not well understood. Here we show that Sall1, a nuclear transcription factor, is required to maintain the stemness of nephron progenitor cells. Transcriptional profiling of Sall1 mutant cells revealed a striking pattern, marked by the reduction of progenitor genes and amplified expression of renal vesicle differentiation genes. These global changes in gene expression were accompanied by ectopic differentiation at E12.5 and depletion of Six2+Cited1+ cap mesenchyme progenitor cells. These findings highlight a novel role for Sall1 in maintaining the stemness of the progenitor cell pool by restraining their differentiation into renal vesicles.
File Format	HTM / HTML
ISSN	09501991
e-ISSN	14779129
DOI	10.1242/dev.095851
Journal	Development
Issue Number	5
Volume Number	141
Language	English
Publisher	The Company of Biologists
Publisher Date	2014-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Discipline Developmental Discipline Biology Cell Differentiation Physiology Stem Cells Cytology Metabolism Transcription Factors Animals Cell Cycle Genetics Immunohistochemistry In Situ Hybridization Kidney Mice Real-time Polymerase Chain Reaction Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Developmental Biology Molecular Biology

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