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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wei, Zheng Angerer, Lynne M. Angerer, Robert C. |
| Description | Country affiliation: United States Author Affiliation: Wei Z ( National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.); Angerer LM ( National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA.); Angerer RC ( National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892, USA rang@mail.nih.gov.) |
| Abstract | During embryogenesis the sea urchin early pluteus larva differentiates 40-50 neurons marked by expression of the pan-neural marker synaptotagmin B (SynB) that are distributed along the ciliary band, in the apical plate and pharyngeal endoderm, and 4-6 serotonergic neurons that are confined to the apical plate. Development of all neurons has been shown to depend on the function of Six3. Using a combination of molecular screens and tests of gene function by morpholino-mediated knockdown, we identified SoxC and Brn1/2/4, which function sequentially in the neurogenic regulatory pathway and are also required for the differentiation of all neurons. Misexpression of Brn1/2/4 at low dose caused an increase in the number of serotonin-expressing cells and at higher dose converted most of the embryo to a neurogenic epithelial sphere expressing the Hnf6 ciliary band marker. A third factor, Z167, was shown to work downstream of the Six3 and SoxC core factors and to define a branch specific for the differentiation of serotonergic neurons. These results provide a framework for building a gene regulatory network for neurogenesis in the sea urchin embryo. |
| File Format | HTM / HTML |
| ISSN | 09501991 |
| e-ISSN | 14779129 |
| Journal | Development |
| Issue Number | 2 |
| Volume Number | 143 |
| Language | English |
| Publisher | The Company of Biologists |
| Publisher Date | 2016-01-15 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Discipline Developmental Discipline Biology Embryo, Nonmammalian Metabolism Sea Urchins Embryology Animals Body Patterning Genetics Physiology Cytology Eye Proteins Gene Expression Regulation, Developmental Homeodomain Proteins Nerve Tissue Proteins Pou Domain Factors Research Support, N.i.h., Intramural |
| Content Type | Text |
| Resource Type | Article |
| Subject | Developmental Biology Molecular Biology |
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