NDLI: Surface forces and protein adsorption on dextran- and polyethylene glycol-modified polydimethylsiloxane.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Farrell, Megan Beaudoin, Stephen
Description	Country affiliation: United States Author Affiliation: Farrell M ( Department of Chemical Engineering, Purdue University, 480 Stadium Mall Dr., West Lafayette, IN 47907, United States.)
Abstract	Dextran and polyethylene glycol (PEG) are often covalently bound to the surface of polydimethylsiloxane (PDMS) for the purpose of modifying its hydrophilicity and biocompatibility. In this work, the effects of the dextran and PEG on the morphology, wetting, and surface charge of the resulting surfaces were quantified and correlated with changes in the amount of fibrinogen and albumin adsorbed from aqueous solution. PDMS films were functionalized in a microwave oxygen plasma to create surface hydroxyl groups that were subsequently aminated by incubation in a (3-aminopropyl)trimethoxysilane (APTES) solution. Oxidized dextran and PEG-aldehyde were linked to the surface amines via reductive amination. This process resulted in low surface coverage of immobilized PEG in the end-on conformation and a more uniform and dense distribution of side-on immobilized dextran. The immobilized dextran reduced the contact angle of the PDMS film from 109° to 80° and neutralized the zeta potential over the pH range from 3 to 11. An atomic force microscope was used to measure the interaction force between the modified PDMS and a model hydrophobic surface (polystyrene latex) and a model hydrophilic surface (silica) in aqueous solution to show that van der Waals and hydrophobic attractive forces are the dominant forces for protein adsorption in this system. The PEG- and dextran-modified PDMS were exposed to BSA and fibrinogen to test their resistance to protein adsorption. The coatings were ineffective at reducing the adsorption of either molecule, and the dextran-modification of the PDMS caused more BSA to adsorb than in the case of the unmodified PDMS.
File Format	HTM / HTML
ISSN	09277765
e-ISSN	18734367
DOI	10.1016/j.colsurfb.2010.07.059
Journal	Colloids and Surfaces B: Biointerfaces
Issue Number	2
Volume Number	81
Language	English
Publisher	Elsevier
Publisher Date	2010-12-01
Publisher Place	Netherlands
Access Restriction	Open
Subject Keyword	Discipline Chemistry Dextrans Chemistry Fibrinogen Polyethylene Glycols Serum Albumin, Bovine Adsorption Animals Membranes, Artificial Microwaves Oxidation-reduction Polystyrenes Silicon Dioxide Surface Properties Wettability Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Research Support, U.s. Gov't, Non-p.h.s.
Content Type	Text
Resource Type	Article
Subject	Colloid and Surface Chemistry Medicine Physical and Theoretical Chemistry Surfaces and Interfaces Biotechnology

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