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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Salama, Hamed A. Mahmoud, Azza A. Kamel, Amany O. Abdel Hady, Mayssa Awad, Gehanne A. S. |
| Description | Country affiliation: Egypt Author Affiliation: Salama HA ( Department of Pharmaceutical Technology, National Research Center, Dokki, Cairo, Egypt.) |
| Abstract | In this study, new phospholipid based colloidal nanocubic vesicles encapsulating olanzapine for its brain targeting via the nasal route were developed. The nanocubic vesicles were prepared by incorporating non-ionic copolymers, poloxamer 188 or 407, in the lipid bilayer. The effect of phospholipid:poloxamer molar ratio on the physicochemical properties of the nanocubic vesicles was investigated. The in vivo behavior and brain targeting of these vesicles were evaluated in rats. TEM photographs showed that the vesicles looked spherical before adding poloxamer. However, after poloxamer incorporation, the vesicles showed a predominant cubic shape, except those containing phospholipid:poloxamer in the molar ratio 5:1 which were spherical. DSC study confirmed perturbation of the packing characteristics as well as fluidization of the lipid bilayer by the polymer with consequent formation of the nanocubic structure. The mean diameter of the vesicles was in the range of 363-645 nm. All vesicles were elastic and the elasticity was found to depend on both poloxamer type and concentration. The intranasal nanocubic vesicles were significantly more efficient in targeting olanzapine to the brain compared to the liposomal vesicles with drug targeting efficiency values of 100% and 80%, respectively, and absolute bioavailability of 37.9% and 14.9%, respectively. |
| File Format | HTM / HTML |
| ISSN | 09277765 |
| Volume Number | 100 |
| e-ISSN | 18734367 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-12-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Chemistry Antipsychotic Agents Pharmacokinetics Benzodiazepines Drug Carriers Chemical Synthesis Poloxamer Chemistry Administration, Intranasal Administration, Intravenous Animals Administration & Dosage Biological Availability Brain Chemistry Chromatography, Liquid Drug Delivery Systems Elasticity Lipid Bilayers Liposomes Male Mass Spectrometry Particle Size Phospholipids Rats Rats, Wistar Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Medicine Physical and Theoretical Chemistry Surfaces and Interfaces Biotechnology |
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