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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Flasinski, Michal Hac-Wydro, Katarzyna Wydro, Pawel Broniatowski, Marcin Dynarowicz-Latka, Patrycja |
| Description | Author Affiliation: Flasinski M ( Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland. Electronic address: flasinsk@chemia.uj.edu.pl.); Hac-Wydro K ( Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.); Wydro P ( Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.); Broniatowski M ( Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.); Dynarowicz-Latka P ( Faculty of Chemistry, Jagiellonian University, Ingardena 3, 30-060 Kraków, Poland.) |
| Abstract | Single-chained ether phospholipids comprise a class of both natural (PAF, lyso-PAF) and synthetic (edelfosine, ED) compounds possessing confirmed extensive biological activities. Among them ED is known to exhibit antineoplastic properties, while PAF and its lyso-precursor are lipids implicated e.g. in the functioning of organism immune system. In our study the interactions of ED, PAF and lyso-PAF with sphingomyelin (SM) being one of the main lipid found in a high concentration in membrane microdomains, like lipid rafts, were investigated in mixed monolayers at the air/water interface. The traditional Langmuir methodology was complemented with modern physicochemical techniques: Grazing incidence X-ray diffraction and Brewster angle microscopy. The investigated compounds, i.e.: platelet activating factor (PAF), (lyso-PAF) and edelfosine were selected because of their highly different physiological properties despite very similar chemical structure and evidenced membrane activity. The obtained results demonstrate that all the investigated three single-chained phospholipids cause strong modification of the model membrane properties in a concentration dependent manner. It has been proved that there are significant differences regarding the influence of the single-chained lipids on model SM membrane--in the region of low concentration, edelfosine was found to be the most effective among all the investigated compounds. The collected data shed new light onto the membrane behavior of the investigated herein biochemically active compounds, which can be of help in understanding their different biological activity and designing of new, more biocompatible drugs. |
| File Format | HTM / HTML |
| ISSN | 09277765 |
| Volume Number | 111 |
| e-ISSN | 18734367 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Chemistry Air Ether Chemistry Microscopy Methods Sphingomyelins Water X-ray Diffraction Platelet Activating Factor Metabolism Temperature Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Medicine Physical and Theoretical Chemistry Surfaces and Interfaces Biotechnology |
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