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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sankar, Rajavelu Murali Seeni Meera, Kamal Mohamed Samanta, Debasis Jithendra, Panneerselvam Mandal, Asit Baran Jaisankar, Sellamuthu N. |
| Description | Country affiliation: India Author Affiliation: Sankar RM ( Polymer Division, Council of Scientific and Industrial Research (CSIR) - Central Leather Research Institute (CLRI), Adyar, Chennai 600020, Tamil Nadu, India.) |
| Abstract | We report a simple and facile method to prepare a novel pH sensitive polyampholyte nanogel by copolymerizing vinylimidazole (VIM) with acrylic acid (AA) using functionalized single-walled carbon nanotubes (f-SWCNTs) (as reinforcing material) and cyanuric chloride via an intermolecular quaternization reaction. The polyampholyte nanogels have been characterized by various microscopic and spectroscopic methods. These studies reveal that incorporation of nanotubes in cross-linked copolymer of poly(vinylimidazole-co-acrylic acid) (PVI-co-AA) form polyampholyte nanogel with enhanced physical properties. The thermal experiments show that the introduction of f-SWCNTs into PVI-co-AA has significant impact on the thermal stability of nanogels. The rheological study showed that the nanogel is more viscoelastic than native gel. MTT assay indicates that the prepared polyampholyte gels possess biocompatibility and cell viability. The nanogel is also useful material to load water-soluble drug such as promethazine hydrochloride. The releasing profile of the drug from the nanogel clearly shows the pH-sensitive property of the material. |
| File Format | HTM / HTML |
| ISSN | 09277765 |
| Volume Number | 112 |
| e-ISSN | 18734367 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2013-12-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Chemistry Ampholyte Mixtures Chemistry Drug Delivery Systems Hydrogels Nanotubes, Carbon Drug Carriers Drug Stability Hot Temperature Hydrogen-ion Concentration Imidazolines Magnetic Resonance Spectroscopy Microscopy, Electron, Scanning Ultrastructure Polyvinyls Promethazine Administration & Dosage Rheology Spectrophotometry Spectroscopy, Fourier Transform Infrared Spectrum Analysis, Raman Viscosity Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Medicine Physical and Theoretical Chemistry Surfaces and Interfaces Biotechnology |
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