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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Abruzzo, Angela Zuccheri, Giampaolo Belluti, Federica Provenzano, Simona Verardi, Laura Bigucci, Federica Cerchiara, Teresa Luppi, Barbara Calonghi, Natalia |
| Description | Author Affiliation: Abruzzo A ( Department of Pharmacy and Biotechnologies, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy. Electronic address: angela.abruzzo2@unibo.it.); Zuccheri G ( Department of Pharmacy and Biotechnologies, Alma Mater Studiorum, University of Bologna INSTM, Centro S3 of CNR-Istituto Nanoscienze, Via Irnerio 48, 40126 Bologna, Italy. Electronic address: giampaolo.zuccheri@unibo.it.); Belluti F ( Department of Pharmacy and Biotechnologies, Alma Mater Studiorum, University of Bologna, Via Belmeloroâ 6, 40126 Bologna, Italy. Electronic address: federica.bigucci@unibo.it.); Provenzano S ( Department of Pharmacy and Biotechnologies, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy. Electronic address: simona.provenzano@hotmail.it.); Verardi L ( Department of Pharmacy and Biotechnologies, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy. Electronic address: laura.verardi2@unibo.it.); Bigucci F ( Department of Pharmacy and Biotechnologies, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy.); Cerchiara T ( Department of Pharmacy and Biotechnologies, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy. Electronic address: teresa.cerchiara2@unibo.it.); Luppi B ( Department of Pharmacy and Biotechnologies, Alma Mater Studiorum, University of Bologna, Via San Donato 19/2, 40127 Bologna, Italy. Electronic address: barbara.luppi@unibo.it.); Calonghi N ( Department of Pharmacy and Biotechnologies, Alma Mater Studiorum, University of Bologna, Via Irnerio 48, 40126 Bologna, Italy. Electronic address: natalia.calonghi@unibo.it.) |
| Abstract | The aim of this study was to develop chitosan-based nanoparticles that could encapsulate lipophilic molecules and deliver them to cancer cells. Nanoparticles were prepared with different molar ratios of chitosan, hyaluronic acid and sulphobutyl-ether-ß-cyclodextrin and with or without curcumin. The nanosystems were characterized in terms of their size, zeta potential, morphology, encapsulation efficiency and stability in different media. Intestinal epithelial and colorectal cancer cells were treated with unloaded nanoparticles in order to study their effect on cellular membrane organization and ROS production. Finally, in vitro assays on both cellular lines were performed in order to evaluate the ability of nanoparticles to promote curcumin internalization and to study their effect on cell proliferation and cell cycle. Results show that nanoparticles were positively charged and their size increased with the increasing amounts of the anionic excipient. Nanoparticles showed good encapsulation efficiency and stability in water. Unloaded nanoparticles led to a change in lipid organization in the cellular membrane of both cell lines, without inducing ROS generation. Confocal microscopy, cell proliferation and cell cycle studies allowed the selection of the best formulation to limit curcumin cytotoxicity in normal intestinal epithelial cells and to reduce cancer cell proliferation. The latter was the result of the increase of expression for genes involved in apoptosis. |
| File Format | HTM / HTML |
| ISSN | 09277765 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Volume Number | 145 |
| e-ISSN | 18734367 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-09-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Medicine Physical and Theoretical Chemistry Surfaces and Interfaces Biotechnology |
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