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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Puxiu Wang, Qian Ren, Tianyang Gong, Haoyu Gou, Jingxin Zhang, Yu Cai, Cuifang Tang, Xing |
| Description | Author Affiliation: Wang P ( Department of Pharmaceutics, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 10016, Liaoning, PR China. Electronic address: wpx609612@sina.com.); Wang Q ( Department of Pharmaceutics, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 10016, Liaoning, PR China. Electronic address: wangqmoyu@163.com.); Ren T ( Department of Pharmaceutics, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 10016, Liaoning, PR China. Electronic address: 267261211@qq.com.); Gong H ( Department of Pharmaceutics, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 10016, Liaoning, PR China. Electronic address: 976724171@qq.com.); Gou J ( Department of Pharmaceutics, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 10016, Liaoning, PR China. Electronic address: 837412837@qq.com.); Zhang Y ( Department of Pharmaceutics, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 10016, Liaoning, PR China. Electronic address: 55211933@qq.com.); Cai C ( Department of Pharmaceutics, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 10016, Liaoning, PR China. Electronic address: caicuifang@163.com.); Tang X ( Department of Pharmaceutics, College of Pharmacy, Shenyang Pharmaceutical University, Shenyang 10016, Liaoning, PR China. Electronic address: tangpharm@126.com.) |
| Abstract | Pluronic F127 and PEG as a multi-gel-core were used to prepare Exenatide-loaded microspheres and store the drug within the microspheres. Also, the sol-gel transition and novel functions of the Pluronic F127-PEG gel core were investigated.Microspheres with a multi-gel-core (GCMs) and without a multi-gel-core (Ms) were compared in terms of the rate of PLGA degradation, therelease kinetics in vitro and the efficacy in KKAy mice. The drug release of GCMs was at a constant rate, and slower than Ms. In addition, after the KKAy mice were given Exenatide for 55days, the blood glucose concentration and HbA1c concentration in the GCMs group were lower than that in the Ms group. The obtained results demonstrated that a single injection of GCMs allowed the mice to maintain a stable blood glucose concentration for two weeks and their body weight was reduced more effectively than that in the Ms group. In addition, GCMs had a longer interval between dosing (two weeks) and a lower dosage(2.4µg/kg) than Bydureon(®) (one week, 33µg/kg). The bioactivity and release of macromolecular Exenatide was improved by the multi-gel-core structure:(1)The hydrophilic Exenatide tended to partition into the PEG chains of F127 and PEG homopolymer, and so it was protected from the organic solvent and vigorous stirring; (2)The macromolecular Exenatide was released both by diffusing through the hydrophilic F127-PEG chains and hydrophobic PLGA. |
| File Format | HTM / HTML |
| ISSN | 09277765 |
| Journal | Colloids and Surfaces B: Biointerfaces |
| Volume Number | 147 |
| e-ISSN | 18734367 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-11-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Content Type | Text |
| Resource Type | Article |
| Subject | Colloid and Surface Chemistry Medicine Physical and Theoretical Chemistry Surfaces and Interfaces Biotechnology |
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