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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mauricio, Marcos R. da Costa, Pablo G. Haraguchi, Shirani K. Guilherme, Marcos R. Muniz, Edvani C. Rubira, Adley F. |
| Description | Country affiliation: Brazil Author Affiliation: Mauricio MR ( Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.); da Costa PG ( Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.); Haraguchi SK ( Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.); Guilherme MR ( Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.); Muniz EC ( Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil.); Rubira AF ( Grupo de Materiais Poliméricos e Compósitos (GMPC) - Department of Chemistry, State University of Maringá, Av. Colombo, 5790, CEP 87020-900 Maringá, Paraná, Brazil. Electronic address: afrubira@uem.br.) |
| Abstract | This work describes the preparation of a microhydrogel composite from cellulose nanowhiskers (CNW) and starch in an ultrasound assisted-emulsion. CNW, which showed rod-like morphology, was obtained by acid hydrolysis of cane-based cellulose. The introduction of vinyl bonds to both CNW and starch enabled us to create the microhydrogel composite in which CNW played a role as a covalent cross-linker. Furthermore, CNW may act as an emulsifying agent for emulsion, improving both sphericity and homogeneity of the microparticles. The drug release was regulated in response to changes in the CNW amounts. The modeling of the release kinetics indicated that the drug release is driven by an anomalous mechanism and that the addition of CNW to starch microparticles led to differences in that mechanism. The release rate became ca. 2.9 times slower when CNW is added. When combined with starch, CNW played a role as a retardant factor for drug release. |
| File Format | HTM / HTML |
| ISSN | 01448617 |
| Volume Number | 115 |
| e-ISSN | 18791344 |
| Journal | Carbohydrate Polymers |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-22 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Biochemistry__semicolon__materials Discipline Science Cellulose Chemistry Drug Delivery Systems Hydrogels Nanostructures Starch Drug Liberation Hydrolysis Microscopy, Electron, Scanning Microscopy, Electron, Transmission Ultrastructure Saccharum Spectroscopy, Fourier Transform Infrared Vitamin B 12 X-ray Diffraction Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Materials Chemistry Polymers and Plastics |
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