NDLI: Calcium supplementation and bone mineral accretion in Chinese adolescents aged 12-14 years: a 12-month, dose-response, randomised intervention trial.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Ma, Xiao-ming Huang, Zhen-wu Yang, Xiao-guang Su, Yi-xiang
Spatial Coverage	China
Description	Author Affiliation: Ma XM ( Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.); Huang ZW ( Key Lab of Trace Element Nutrition of Ministry of Health, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention,Beijing100021,People's Republic of China.); Yang XG ( Key Lab of Trace Element Nutrition of Ministry of Health, National Institute for Nutrition and Food Safety, Chinese Center for Disease Control and Prevention,Beijing100021,People's Republic of China.); Su YX ( Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University,Guangzhou510080,People's Republic of China.)
Abstract	A 12-month, dose-response, randomised, intervention trial was conducted to determine adequate Ca intake levels for Chinese adolescents by investigating the effect of Ca supplementation on bone mineral accretion. A total of 220 Han adolescents (111 girls and 109 boys) aged 12-14 years were recruited. All subjects were randomly divided into three groups. The bone mineral content (BMC) and bone mineral density (BMD) of the whole body, lumbar spine (L1-L4), left hip and femoral neck were measured by dual-energy X-ray absorptiometry. Girls in the high-Ca group (actual Ca intake: 1243 (sd 193) mg/d) exhibited greater increases in the femoral neck BMC compared with those in the low-Ca group (9·7 v. 6·4 %, P =0·04) over the 1-year intervention period. The increases in femoral neck BMC were greater in boys in the high-Ca and medium-Ca groups (actual Ca intake: 985 (sd 168) mg/d) than in those in the low-Ca group (15·7 v. 11·7 %, P =0·03; 15·8 v. 11·7 %, P =0·03). Ca supplementation had significant effects on the whole-body BMC and BMD in subjects with physical activity levels>34·86 metabolic equivalents and on the spine BMD and BMC and BMD of most sites in subjects with Tanner stage < 3. Increasing Ca intake levels with Ca supplementation enhanced femoral neck mineral acquisition in Chinese adolescents. Furthermore, high physical activity levels and low Tanner stage appeared to significantly contribute to the effect of Ca supplementation on bone mass. Whether this is a lasting beneficial effect leading to the optimisation of peak bone mass needs to be determined in other long-term prospective studies.
File Format	HTM / HTML
ISSN	00071145
Issue Number	9
Volume Number	112
e-ISSN	14752662
Journal	British Journal of Nutrition
Language	English
Publisher	Cambridge University Press (on behalf of The Nutrition Society)
Publisher Date	2014-11-14
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Nutritional Discipline Sciences Bone Density Drug Effects Calcium, Dietary Administration & Dosage Absorptiometry, Photon Adolescent Animals Child China Diet Dietary Supplements Dose-response Relationship, Drug Double-blind Method Energy Metabolism Exercise Female Femur Neck Food, Preserved Humans Longitudinal Studies Lumbar Vertebrae Male Milk Motor Activity Puberty Physiology Sex Factors Questionnaires Journal Article Randomized Controlled Trial Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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