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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Scott, Andrew V. Nagababu, Enika Johnson, Daniel J. Kebaish, Khaled M. Lipsitz, Joshua A. Dwyer, Ian M. Zuckerberg, Gabriel S. Barodka, Viachaslau M. Berkowitz, Dan E. Frank, Steven M. |
| Description | Author Affiliation: Scott AV ( From the Departments of *Anesthesiology/Critical Care Medicine, Orthopedic Surgery, and Biomedical Engineering, The Johns Hopkins Medical Institutions, Baltimore, Maryland.) |
| Abstract | BACKGROUND: Stored red blood cells (RBCs) are deficient in 2,3-diphosphoglycerate (2,3-DPG), but it is unclear how autologous salvaged blood (ASB) compares with stored blood and how rapidly 2,3-DPG levels return to normal after transfusion. Therefore, we compared levels of 2,3-DPG in stored versus ASB RBCs and in patients' blood after transfusion. METHODS: Twenty-four patients undergoing multilevel spine fusion surgery were enrolled. We measured 2,3-DPG and the oxyhemoglobin dissociation curve (P50) in samples taken from the ASB and stored blood bags before transfusion and in blood samples drawn from patients before and after transfusion. RESULTS: The mean storage duration for stored RBCs was 24 ± 8 days. Compared with fresh RBCs, stored RBCs had decreased 2,3-DPG levels (by approximately 90%; P < 0.0001) and a decreased P50 (by approximately 30%; P < 0.0001). However, ASB RBCs did not exhibit these changes. The mean 2,3-DPG concentration decreased by approximately 20% (P < 0.05) in postoperative blood sampled from patients who received 1 to 3 stored RBC units and by approximately 30% (P < 0.01) in those who received ≥4 stored RBC units. 2,3-DPG was unchanged in patients who received no stored blood or ASB alone. After surgery, 2,3-DPG levels recovered gradually over 3 postoperative days in patients who received stored RBCs. CONCLUSIONS: Stored RBCs, but not ASB RBCs, have decreased levels of 2,3-DPG and a left-shift in the oxyhemoglobin dissociation curve. Postoperatively, 2,3-DPG levels remain below preoperative baseline levels for up to 3 postoperative days in patients who receive stored RBCs but are unchanged in those who receive only ASB RBCs. |
| File Format | HTM / HTML |
| ISSN | 00032999 |
| Issue Number | 3 |
| Volume Number | 122 |
| e-ISSN | 15267598 |
| Journal | Anesthesia & Analgesia |
| Language | English |
| Publisher | Lippincott Williams & Wilkins |
| Publisher Date | 2016-03-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Anesthesiology 2,3-diphosphoglycerate Blood Blood Transfusion, Autologous Erythrocytes Chemistry Operative Blood Salvage Adult Aged Blood Preservation Erythrocyte Transfusion Female Humans Male Middle Aged Oxyhemoglobins Analysis Spinal Fusion Comparative Study Journal Article Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anesthesiology and Pain Medicine |
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