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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Ebrahimzadeh, Homeira Yamini, Yadollah Firozjaei, Hamid Abedi Kamarei, Fahimeh Tavassoli, Najmeh Rouini, Mohammad Reza |
| Description | Country affiliation: Iran Author Affiliation: Ebrahimzadeh H ( Department of Chemistry, Shahid Beheshti University, G.C., Evin, Tehran, Iran. h-ebrahim@sbu.ac.ir) |
| Abstract | Three-phase hollow fiber microextraction technique combined with high performance liquid chromatography-ultra violet (HPLC-UV) was applied for the extraction and determination of gabapentin in biological fluids. Gabapentin (GBP) was derivatized with 1-fluoro-2,4-dinitrobenzene, as a UV absorbent agent in borate buffer (pH 8.2) before extraction. The derivative product of GBP was extracted from the 8.5 mL of acidic solution (source phase) into an organic phase (dihexyl ether) impregnated in the pores of a hollow fiber and finally back-extracted into 24 microL of the basic solution (pH 9.1) located inside the lumen of the hollow fiber (receiving phase). The extraction took place due to pH gradient between the inside and outside of the hollow fiber membrane. In order to achieve maximum extraction efficiency, different parameters affecting the extraction conditions were optimized. Under the optimized conditions, preconcentration factor of 95 and detection limit (LOD) of 0.2 microg L(-1) were obtained. The calibration graph was linear within the range of 0.6-5000 microg L(-1). Finally, the feasibility of the proposed method was successfully confirmed by extraction and determination of GBP in human urine and plasma samples in the range of microgram per liter and suitable results were obtained (RSDs<6.3%). |
| File Format | HTM / HTML |
| ISSN | 00032670 |
| Issue Number | 2 |
| Volume Number | 665 |
| e-ISSN | 18734324 |
| Journal | Analytica Chimica Acta |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-04-30 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Amines Analysis Analgesics Chromatography, High Pressure Liquid Methods Cyclohexanecarboxylic Acids Gamma-aminobutyric Acid Blood Urine Chemical Fractionation Filtration Humans Hydrogen-ion Concentration Spectrophotometry, Ultraviolet Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Environmental Chemistry Analytical Chemistry Biochemistry |
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