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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Roushani, Mahmoud Shahdost-fard, Faezeh |
| Description | Author Affiliation: Roushani M ( Department of Chemistry, Ilam University, Ilam, Iran. Electronic address: mahmoudroushani@yahoo.com.); Shahdost-fard F ( Department of Chemistry, Ilam University, Ilam, Iran.) |
| Abstract | Based on the conformational changes of the aptamer-functionalized gold nanoparticles (AuNPs) onto MWCNTs/IL/Chit nanocomposite as the support platform, we have developed a sensitive and selective electrochemical aptasensor for the detection of cocaine. The 5'-amine-3'-AuNP terminated aptamer is covalently attached to a MWCNTs/IL/Chit nanocomposite. The interaction of cocaine with the aptamer functionalized AuNP caused the aptamer to be folded and the AuNPs with negative charge at the end of the aptamer came to the near of electrode surface therefore, the electron transfer between ferricyanide (K3Fe(CN)6) as redox probe and electrode surface was inhibited. A decreased current of (K3Fe(CN)6) was monitored by differential pulse voltammetry technique. In an optimized condition the calibration curve for cocaine concentration was linear up to 11 µM with detection limit (signal-to-noise ratio of 3) of 100 pM. To test the selectivity of the prepared aptasensor sensing platform applicability, some analgesic drugs as the interferes were examined. The potential of the aptasensor was successfully applied for measuring cocaine concentration in human blood serum. Based on our experiments it can be said that the present method is absolutely beneficial in developing other electrochemical aptasensor. |
| File Format | HTM / HTML |
| ISSN | 00032670 |
| Volume Number | 853 |
| e-ISSN | 18734324 |
| Journal | Analytica Chimica Acta |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-01-01 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Aptamers, Nucleotide Chemistry Cocaine Analysis Electrochemical Techniques Gold Metal Nanoparticles Blood Electrodes Ferrocyanides Humans Oxidation-reduction Journal Article |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Environmental Chemistry Analytical Chemistry Biochemistry |
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