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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | André, Silvère Cristau, Lydia Saint Gaillard, Sabine Devos, Olivier Calvosa, Éric Duponchel, Ludovic |
| Description | Country affiliation: France Author Affiliation: André S ( LASIR CNRS UMR 8516, Université de Lille, Sciences et Technologies, 59655 Villeneuve d'Ascq Cedex, France.); Cristau LS ( Sanofi Pasteur, 1541 Avenue Marcel Mérieux, 69280 Marcy-l'Étoile, France.); Gaillard S ( Sanofi Pasteur, 1541 Avenue Marcel Mérieux, 69280 Marcy-l'Étoile, France.); Devos O ( LASIR CNRS UMR 8516, Université de Lille, Sciences et Technologies, 59655 Villeneuve d'Ascq Cedex, France.); Calvosa É ( Sanofi Pasteur, 1541 Avenue Marcel Mérieux, 69280 Marcy-l'Étoile, France.); Duponchel L ( LASIR CNRS UMR 8516, Université de Lille, Sciences et Technologies, 59655 Villeneuve d'Ascq Cedex, France. Electronic address: ludovic.duponchel@univ-lille1.fr.) |
| Abstract | The Food and Drug Administration's (FDA) process analytical technology (PAT) framework has been initiated to encourage drug manufacturers to develop innovative techniques in order to better understand their processes and institute high level quality control which allows action at any point in the manufacturing process. While Raman spectroscopy and chemometrics have been successfully used to predict concentration of conventional metabolites in cell cultures, it is really not the case for active substances. Thus, we propose, for the first time, an in-line and real-time prediction of recombinant antibody titer using an immersion probe link to a spectrometer without the tacking of samples. A good robustness of the method is observed on different culture batches and the contamination risk is drastically reduced which is an important issue in biotechnology manufacturing processes. |
| File Format | HTM / HTML |
| ISSN | 00032670 |
| Volume Number | 892 |
| e-ISSN | 18734324 |
| Journal | Analytica Chimica Acta |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-10 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Antibodies, Monoclonal Analysis Recombinant Proteins Spectrum Analysis, Raman Animals Genetics Metabolism Bioreactors Cho Cells Cricetinae Cricetulus Least-squares Analysis Quality Control Biosynthesis Standards Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Environmental Chemistry Analytical Chemistry Biochemistry |
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