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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Wang, Jiaxi Wang, Yanan Gao, Mingxia Zhang, Xiangmin Yang, Pengyuan |
| Description | Country affiliation: China Author Affiliation: Wang J ( Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.); Wang Y ( Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.); Gao M ( Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China. Electronic address: mxgao@fudan.edu.cn.); Zhang X ( Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.); Yang P ( Department of Chemistry and Institutes of Biomedical Sciences, Fudan University, Shanghai 200433, China.) |
| Abstract | Selective enrichment of glycopeptides or phosphopeptides with great biological significance is essential for high-throughput mass spectrometry analysis. However, most previously reported methods only focused on enriching either glycopeptides or phosphopeptides rather than enriching them both. In this work, for the first time, a facile route was developed for the synthesis of polyamidoxime polymers with intrinsic hydrophilic skeletons and attractive long chain structure. The polyamidoxime materials (co-PAN) were synthesized from polyacrylonitrile (PAN) precursor and were successfully used for selective enrichment of glycopeptides. After that, co-PAN as a matrix functionalized with titanium ions (co-PAN@Ti(4+)) could efficiently enrich phosphopeptides. The performances of the polymers for sequential selective and effective enrichment of glycopeptides and phosphopeptides were evaluated with standard peptide mixtures and human serum. Moreover, the efficiency of enrichment of the material was still retained after being used repeatedly. These results demonstrated that the polymers showed great potential in the practical application of proteomics. |
| File Format | HTM / HTML |
| ISSN | 00032670 |
| Volume Number | 907 |
| e-ISSN | 18734324 |
| Journal | Analytica Chimica Acta |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2016-02-11 |
| Publisher Place | Netherlands |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Analytical Discipline Chemistry Glycoproteins Analysis Phosphoproteins Proteome Solid Phase Extraction Methods Humans Hydrophobic And Hydrophilic Interactions Microscopy, Electron, Scanning Microscopy, Electron, Transmission Reproducibility Of Results Spectrometry, Mass, Matrix-assisted Laser Desorption-ionization Journal Article Research Support, Non-u.s. Gov't |
| Content Type | Text |
| Resource Type | Article |
| Subject | Spectroscopy Environmental Chemistry Analytical Chemistry Biochemistry |
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