NDLI: Polymorphisms in KCNE1 or KCNE3 are not associated with Ménière disease in the Caucasian population.

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Polymorphisms in KCNE1 or KCNE3 are not associated with Ménière disease in the Caucasian population.

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Polymorphisms in KCNE1 or KCNE3 are not associated with Ménière disease in the Caucasian population.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Campbell, Colleen A. Della Santina, Charley C. Meyer, Nicole C. Smith, Nancy B. Myrie, Oluwaseun A. Stone, Edwin M. Fukushima, Kuni Califano, Joseph Carey, John P. Hansen, Marlan R. Gantz, Bruce J. Minor, Lloyd B. Smith, Richard J. H.
Description	Country affiliation: United States Author Affiliation: Campbell CA ( Molecular Otolaryngology Research Laboratories, Department of Otolaryngology - Head and Neck Surgery, University of Iowa, Iowa City, IA 52242, USA.)
Abstract	Ménière disease (MD) is a complex disorder of unknown etiology characterized by the symptom triad of vertigo, sensorineural hearing loss, and tinnitus. Its reported incidence is 1-2 per 1,000 in Caucasians and 0.03-0.37 per 1,000 in Japanese. Doi et al. [Doi et al. (2005); ORL J Otorhinolaryngol Relat Spec 67:289-293] recently reported that two single nucleotide polymorphisms (SNPs) in KCNE1 and KCNE3 are associated with MD in Japanese subjects. Consistent with this possibility, these two genes encode potassium channels that are expressed in the stria vascularis and endolymphatic sac, respectively, and their role in ion transport suggests that they may be important in inner ear homeostasis. To establish whether a similar association exists in the Caucasian MD population, we sequenced the coding regions and exon-intron boundaries of both genes in 180 Caucasian persons with MD and 180 matched Caucasian controls. Neither of the two reported SNPs was significantly associated with MD when compared to the Caucasian controls (KCNE1, P = 0.55; KCNE3, P = 0.870). Comparison of allele frequencies between the Japanese MD population and our study population revealed no significant difference between groups (KCNE1, P = 0.90; KCNE3, P = 0.862), suggesting that the significant differences reported in the Japanese study arose from their control population. Six additional SNPs in both KCNE1 and KCNE3 were genotyped and none was associated with MD. Population stratification within our MD and Caucasian control population was excluded. Our data show that SNPs in KCNE1 and KCNE3 are not associated with MD in Caucasians.
File Format	HTM / HTML
ISSN	15524825
Issue Number	1
Volume Number	152A
e-ISSN	15524833
Journal	American Journal of Medical Genetics Part A
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2010-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Human Discipline Genetics European Continental Ancestry Group Meniere Disease Genetics Polymorphism, Single Nucleotide Potassium Channels, Voltage-gated Aged Case-control Studies Female Humans Male Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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