NDLI: Risk for ingestion of toxic substances in children with Prader-Willi syndrome.

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Risk for ingestion of toxic substances in children with Prader-Willi syndrome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	McCandless, Shawn E. Powell, Karen Potter Sandberg, Ulrika
Description	Country affiliation: United States Author Affiliation: McCandless SE ( Case Western Reserve University and University Hospitals Case Medical Center, Cleveland, Ohio, USA. shawn.mccandless@case.edu)
Abstract	Individuals with Prader-Willi syndrome (PWS) have several common findings that may predispose to ingestion of potentially dangerous items. This study examined whether individuals with PWS have an increased prevalence of toxic ingestions. A survey regarding history of ingestions in PWS individuals and sibling controls was designed, piloted, and distributed on-line. The subjects were individuals with PWS (N = 129). The subjects' non-PWS siblings served as controls (N = 134). Participants who completed the anonymous online survey were either the parents or the primary caretaker of individuals with PWS. Responses were submitted by 141 participants, providing information about 130 PWS subjects (M/F: 66:64) and 134 sibling controls. Subjects and controls ranged in age from 2 to 18 years at the time of the survey. Eleven participants did not answer the questions regarding ingestions. History of toxic ingestion was more prevalent in PWS subjects (20% vs. 2% of controls). Several features of PWS, including history of searching for food and eating unusual objects, along with decreased cognitive ability, appeared to associate with increased prevalence of toxic ingestion in PWS individuals. PWS children appear to have an â¼12-fold increased risk of ingesting toxins compared to the general population. Geneticists should include this information in counseling and in recommendations to primary care providers. Also, poison control centers need to be aware of this association and of the physiological and behavioral aspects of PWS that may complicate the diagnosis and management of a toxic ingestion.
File Format	HTM / HTML
ISSN	15524825
Issue Number	11
Volume Number	158A
e-ISSN	15524833
Journal	American Journal of Medical Genetics Part A
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2012-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Human Discipline Genetics Feeding Behavior Hazardous Substances Prader-willi Syndrome Epidemiology Adolescent Child Child, Preschool Humans Prevalence Risk Questionnaires Journal Article
Content Type	Text
Resource Type	Article
Subject	Genetics Genetics (clinical)

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