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Clinical implications of single cell sequencing for bladder cancer

Content Provider	Tech Science Press
Author	Dionato, Franciele Aparecida Vechia Leme, Patrícia A. F. Reis, Leonardo Oliveira Jalalizadeh, Mehrsa Cristiane, F. Giacomelli Buosi, Keini Assis, Alex Dias Luciana, S. B. Dal Col Bashirichelkasari, Nasim Yadollahvandmiandoab, Reza Aparecida, Franciele A., Patrícia Luciana, S. Giacomelli, Cristiane Assis, Alex Reis, Leonardo
Abstract	Bladder cancer (BC) is the 10th most common cancer worldwide, with about 0.5 million reported new cases and about 0.2 million deaths per year. In this scoping review, we summarize the current evidence regarding the clinical implications of single-cell sequencing for bladder cancer based on PRISMA guidelines. We searched PubMed, CENTRAL, Embase, and supplemented with manual searches through the Scopus, and Web of Science for published studies until February 2023. We included original studies that used at least one single-cell technology to study bladder cancer. Forty-one publications were included in the review. Twenty-nine studies showed that this technology can identify cell subtypes in the tumor microenvironment that may predict prognosis or response to immune checkpoint inhibition therapy. Two studies were able to diagnose BC by identifying neoplastic cells through single-cell sequencing urine samples. The remaining studies were mainly a preclinical exploration of tumor microenvironment at single cell level. Single-cell sequencing technology can discriminate heterogeneity in bladder tumor cells and determine the key molecular properties that can lead to the discovery of novel perspectives on cancer management. This nascent tool can advance the early diagnosis, prognosis judgment, and targeted therapy of bladder cancer.
Related Links	https://www.techscience.com/or/v32n4/55764
Starting Page	597
Ending Page	605
ISSN	09650407
DOI	10.32604/or.2024.045442
Issue Number	4
Journal	Oncology Research (OR)
Volume Number	32
e-ISSN	15553906
Language	English
Publisher Date	2024-03-20
Access Restriction	Open
Subject Keyword	Single-cell sequencing Tumor microenvironment Transitional cell carcinoma Scoping review Bladder cancer Tumor heterogeneity Urothelial carcinoma Immunotherapy
Content Type	Text
Resource Type	Article
Subject	Cancer Research

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