NDLI: You Cannot Always Win: Molecular Bases of the Resistance of Picornaviruses to Win Compounds

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You Cannot Always Win: Molecular Bases of the Resistance of Picornaviruses to Win Compounds

Content Provider	Taylor & Francis Online
Author	Zhelev, Nikolai Mustaffa, Munira
Abstract	The Picornaviridae family comprises a heterogeneous group of non-enveloped viruses with genome consisting of a single positivesense RNA strand. Infections with picornaviruses are very common in humans, producing a spectrum of clinical outcomes, ranging from asymptomatic infection and mild respiratory illness, to meningitis, myocarditis, pericarditis, and enterovirus-induced septic syndrome. Most picornaviruses seem to develop resistance quite effectively against almost any chemotherapeutic agent that modern science has developed, presenting a truly formidable challenge to modern healthcare. For some time, it has been hoped that synthetic agents mimicking the naturally occurring sphingosine-like molecule occupying the hydrophobic pocket in the viral capsid may be useful as antiviral agents, but it has been repeatedly demonstrated that resistance to the pocket-binding antivirals develops quite rapidly and that viral strains dependent on the chemotherapeutic may emerge. Several pocket-binding pyrazole drugs have entered clinical trials so far, but as of now, none of these have been licensed by the FDA, despite the extensive clinical trials. Apparently, the search for means of prevention of infection with rhino- and enteroviruses or an etiotropic cure for the conditions related to infections with picornaviruses is still ongoing.
Starting Page	2826
Ending Page	2828
Page Count	3
File Format	PDF HTM / HTML
ISSN	13102818 13143530
DOI	10.5504/BBEQ.2012.0022
Journal	Biotechnology & Biotechnological Equipment
Volume Number	26
Issue Number	2
Language	English
Publisher	Taylor & Francis
Publisher Date	2014-04-16
Access Restriction	Open
Subject Keyword	Picornaviruses Pocket factors Resistance to antivirals WIN compounds
Content Type	Text
Subject	Biotechnology

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