NDLI: Oxidative Imbalance in Children and Adolescents with Autism Spectrum Disorder

Please wait, while we are loading the content...

Severity of Depression and Anxiety Symptoms is Associated with Increased Arterial Stiffness in Depressive Disorder Patients Undergoing Psychiatric Treatment

Psychometric Properties of the Turkish PTSD-Short Scale in a Sample of Undergraduate Students

Turkish Validity & Reliability of The Quick Inventory of Depressive Symptomatology Adolescent Version (QIDS-A17-SR) In Comparison with The Beck Depression Inventory-II Among Late Adolescents

Clinical Course and Management of Drug-Induced Catatonia and Paranoid Behavior in an Adolescent

Suicide Attempt with High Dose Long Acting Methylphenidate Ingestion: A Case Presentation

Neutropenia and Thrombocytopenia Induced By Quetiapine Monotherapy: A Case Report and Review of Literature

A Case of Chronic Schizophrenia Who were Switched from Combined Treatment to Monotherapy and Achieved a Decrease in Positive Symptoms after Lowering the Clozapine Dose

Oxidative Imbalance in Children and Adolescents with Autism Spectrum Disorder

Content Provider	Taylor & Francis Online
Author	Kaptanoglu, Bunyamin Buber, Ahmet Tuncer, Omer Faruk Kardesler, Aysen Cetin Alacam, Huseyin Basay, Burge Kabukcu Ozturk, Onder Enli, Yasar Basay, Omer Dogan, Mustafa
Abstract	Objective: Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by impairments in social interactions and behavioral problems. Various genetic and environmental factors, including oxidative stress, are claimed to play a role in the etiopathogenesis of ASD. In this study, we aimed to examine the status of oxidative metabolism in ASD and the association between oxidative parameters and ASD symptom severity and subtype of ASD.Method: Thirty-three children and adolescents diagnosed with ASD (16 children diagnosed with autistic disorder, 13 children with pervasive developmental disorder not otherwise specified, and 4 children with Asperger syndrome) according to Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, Text Revision (DSM-IV-TR) and 28 healthy controls, aged 2–17 years, were recruited in this study. Total oxidant status (TOS) and total antioxidant status (TAS) were evaluated using Rel Assay Kit in children and adolescents. The oxidative stress index (OSI) was calculated by dividing the TOS values by the TAS values. Autistic symptoms for these patients were scored on the Childhood Autism Rating Scale (CARS).Results: In patients with ASD, TAS was statistically significantly lower and OSI statistically significantly higher than in healthy controls. There were no statistically significant differences in TOS between the ASD and control groups. There were no statistically significant differences between the subtypes of ASD in terms of oxidative stress parameters. In addition, TAS, TOS, and OSI values did not differ statistically significantly between the patients' CARS groups, and were not associated with the CARS scores of the patients.Conclusion: Our findings suggest that oxidative imbalance is present in ASD and that oxidative stress may play a role in the etiopathogenesis of ASD. Therefore, it is suggested that antioxidants may have beneficial effects on ASD and may be a new therapeutic target in treating ASD.
Starting Page	257
Ending Page	264
Page Count	8
File Format	PDF HTM / HTML
ISSN	10177833 13029657
DOI	10.5455/bcp.20160323105909
Journal	Psychiatry and Clinical Psychopharmacology
Volume Number	26
Issue Number	3
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-11-08
Access Restriction	Open
Subject Keyword	Autism spectrum disorder Total oxidant status Total antioxidant status Oxidative stress index Oxidative stress
Content Type	Text
Resource Type	Article
Subject	Pharmacology (medical) Psychiatry and Mental Health

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index.

Evaluation of Oxidative Metabolism in Child and Adolescent Patients with Attention Deficit Hyperactivity Disorder.

Oxidative parameters, oxidative DNA damage, and urotensin-II in schizoaffective disorder patients

Shorter telomere length in children with autism spectrum disorder is associated with oxidative stress

Assessment of malondialdehyde levels, superoxide dismutase, and catalase activity in children with autism spectrum disorders

Oxidative stress indices in ASD children in Sub-Sahara Africa.

Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index Bipolar Bozuklukta Oksidatif Stresin Total Oksidan Seviye, Total Antioksidan

Oxidative stress and antioxidant status in patients with Bell's palsy

Parenting stress in South Korean mothers of adolescent children with autism spectrum disorder.

Oxidative Imbalance in Children and Adolescents with Autism Spectrum Disorder

Similar Documents

Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index.

Evaluation of Oxidative Metabolism in Child and Adolescent Patients with Attention Deficit Hyperactivity Disorder.

Oxidative parameters, oxidative DNA damage, and urotensin-II in schizoaffective disorder patients

Shorter telomere length in children with autism spectrum disorder is associated with oxidative stress

Assessment of malondialdehyde levels, superoxide dismutase, and catalase activity in children with autism spectrum disorders

Oxidative stress indices in ASD children in Sub-Sahara Africa.

Evaluation of Oxidative Stress in Bipolar Disorder in terms of Total Oxidant Status, Total Antioxidant Status, and Oxidative Stress Index Bipolar Bozuklukta Oksidatif Stresin Total Oksidan Seviye, Total Antioksidan

Oxidative stress and antioxidant status in patients with Bell's palsy

Parenting stress in South Korean mothers of adolescent children with autism spectrum disorder.

Oxidative Imbalance in Children and Adolescents with Autism Spectrum Disorder