NDLI: The CD95 signaling pathway

Content Provider	Taylor & Francis Online
Author	Penna, Aubin Khadra, Nadine Tauzin, Sébastien Legembre, Patrick Vacher, Pierre
Abstract	Our recent findings indicate that cells exposed to transmembrane (m-CD95L) or metalloprotease-cleaved CD95L (cl-CD95L) undergo a localized Ca2+entry that not only inhibits the initial steps of the CD95-mediated apoptotic signal but also promotes cell motility. Based on recent findings published on the non-apoptotic signals induced by CD95, we discuss how m-CD95L and cl-CD95L diverging by their stoichiometry could both contribute to the immune response by first recruiting activated T lymphocytes in the inflamed area and later by eliminating infected and transformed cells.
Starting Page	190
Ending Page	192
Page Count	3
File Format	PDF HTM / HTML
ISSN	19420889
DOI	10.4161/cib.18888
Journal	Communicative & Integrative Biology
Volume Number	5
Issue Number	2
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-03-01
Access Restriction	Open
Subject Keyword	Fas FasL Orai1 PI3K TNF Apoptosis Calcium Lymphocyte Migration
Content Type	Text
Resource Type	Article
Subject	Agricultural and Biological Sciences

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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The CD95 signaling pathway