NDLI: Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II

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Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II

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Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II

Content Provider	Taylor & Francis Online
Author	Gill, Gordon N. Zhang, Yan Zhang, Mengmeng
Abstract	In eukaryotic cells, the transcription of genes is accurately orchestrated both spatially and temporally by the C-terminal domain of RNA polymerase II (CTD). The CTD provides a dynamic platform to recruit different regulators of the transcription apparatus. Different posttranslational modifications are precisely applied to specific sites of the CTD to coordinate transcription process. Regulators of the RNA polymerase II must identify specific sites in the CTD for cellular survival, metabolism, and development. Even though the CTD is disordered in the eukaryotic RNA polymerase II crystal structures due to its intrinsic flexibility, recent advances in the complex structural analysis of the CTD with its binding partners provide essential clues for understanding how selectivity is achieved for individual site recognition. The recent discoveries of the interactions between the CTD and histone modification enzymes disclose an important role of the CTD in epigenetic control of the eukaryotic gene expression. The intersection of the CTD code with the histone code discloses an intriguing yet complicated network for eukaryotic transcriptional regulation.
File Format	PDF HTM / HTML
ISSN	20005121
DOI	10.3402/nano.v1i0.5502
Journal	Nano Reviews & Experiments
Volume Number	1
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2010-08-30
Access Restriction	Open
Subject Keyword	C-terminal domain RNA polymerase II Transcription regulation Phosphorylation CTD code WW domain CID domain SRI domain FF domain Histone code Epigenetic regulation
Content Type	Text
Resource Type	Article

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Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II

Cross-Talk of Phosphorylation and Prolyl Isomerization of the C-terminal Domain of RNA Polymerase II

Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription

Cdc15 Phosphorylates the C-terminal Domain of RNA Polymerase II for Transcription during Mitosis

Cotranscriptional Association of mRNA Export Factor Yra1 with C-terminal Domain of RNA Polymerase II

Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II.

Transcription-independent phosphorylation of the RNA polymerase II C-terminal domain (CTD) involves ERK kinases (MEK1/2)

Rat1p maintains RNA polymerase II CTD phosphorylation balance.

Nuclear c-abl is a coohterminal repeated domain (ctd)-tyrosine (ctd)- tyrosine kinase-specific for the mammalian rna polymerase ii: possible role in transcription elongation. Cell growth differ 10 (1999).

Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II

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Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II

Cross-Talk of Phosphorylation and Prolyl Isomerization of the C-terminal Domain of RNA Polymerase II

Structural determinants for accurate dephosphorylation of RNA polymerase II by its cognate C-terminal domain (CTD) phosphatase during eukaryotic transcription

Cdc15 Phosphorylates the C-terminal Domain of RNA Polymerase II for Transcription during Mitosis

Cotranscriptional Association of mRNA Export Factor Yra1 with C-terminal Domain of RNA Polymerase II

Site-specific methylation and acetylation of lysine residues in the C-terminal domain (CTD) of RNA polymerase II.

Transcription-independent phosphorylation of the RNA polymerase II C-terminal domain (CTD) involves ERK kinases (MEK1/2)

Rat1p maintains RNA polymerase II CTD phosphorylation balance.

Nuclear c-abl is a coohterminal repeated domain (ctd)-tyrosine (ctd)- tyrosine kinase-specific for the mammalian rna polymerase ii: possible role in transcription elongation. Cell growth differ 10 (1999).

Bio-molecular architects: a scaffold provided by the C-terminal domain of eukaryotic RNA polymerase II