NDLI: A proof-of-concept model for the identification of the key events in the infection process with specific reference to Pseudomonas aeruginosa in corneal infections

Please wait, while we are loading the content...

Detection of pandemic strain of influenza virus (A/H1N1/pdm09) in pigs, West Africa: implications and considerations for prevention of future influenza pandemics at the source

First identification of methicillin-resistant Staphylococcus pseudintermedius strains among coagulase-positive staphylococci isolated from dogs with otitis externa in Trinidad, West Indies

Absence of vancomycin-resistant enterococci among highly ESBL-positive crows (Corvus splendens) foraging on hospital waste in Bangladesh

Spatio-temporal variation in prevalence of Rift Valley fever: a post-epidemic serum survey in cattle and wildlife in Kenya

Veterinary syndromic surveillance in practice: costs and benefits for governmental organizations

Campylobacter jejuni sequence types show remarkable spatial and temporal stability in Blackbirds

Molecular methods routinely used to detect Coxiella burnetii in ticks cross-react with Coxiella-like bacteria

Serologic screening for 13 infectious agents in roe deer (Capreolus capreolus) in Flanders

Intestinal spirochaetes (genus Brachyspira) colonise wild birds in the southern Atlantic region and Antarctica

A study of Rift Valley fever virus in Morogoro and Arusha regions of Tanzania – serology and farmers’ perceptions

A trial with IgY chicken antibodies to eradicate faecal carriage of Klebsiella pneumoniae and Escherichia coli producing extended-spectrum beta-lactamases

Helicobacter pylori among patients with symptoms of gastroduodenal ulcer disease in rural Uganda

A proof-of-concept model for the identification of the key events in the infection process with specific reference to Pseudomonas aeruginosa in corneal infections

Hygiene quality and presence of ESBL-producing Escherichia coli in raw food diets for dogs

The abundant free-living amoeba, Acanthamoeba polyphaga, increases the survival of Campylobacter jejuni in milk and orange juice

Mallard or chicken? Comparing the isolation of avian influenza A viruses in embryonated Mallard and chicken eggs

Antimicrobial-resistant and ESBL-producing Escherichia coli in different ecological niches in Bangladesh

Risk factors and potential preventive measures for nephropatia epidemica in Sweden 2011–2012: a case–control study

Evaluation of antibiotic prescription in the Lebanese community: a pilot study

Detection and characterisation of novel bocavirus (genus Bocaparvovirus) and gastroenteritis viruses from asymptomatic pigs in Ireland

Putative connection between zoonotic multiresistant extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli in dog feces from a veterinary campus and clinical isolates from dogs

Role of asymptomatic carriers and weather variables in persistent transmission of malaria in an endemic district of Assam, India

Do open garbage dumps play a role in canine rabies transmission in Biyem-Assi health district in Cameroon?

High proportion of MERS-CoV shedding dromedaries at slaughterhouse with a potential epidemiological link to human cases, Qatar 2014

First evidence of Seoul hantavirus in the wild rat population in the Netherlands

The Network for Evaluation of One Health: evidence-based added value of One Health

Measles in India: Challenges & recent developments

Targets to increase food production: One Health implications

Possible zoonotic transmission of Cryptosporidium felis in a household

One Health: people, animals, and the environment

One Health education meets science

The imperative to develop a human vaccine for the Hendra virus in Australia

The case for a ‘one health’ approach to combating vector-borne diseases

A proof-of-concept model for the identification of the key events in the infection process with specific reference to Pseudomonas aeruginosa in corneal infections

Content Provider	Taylor & Francis Online
Author	Knapp, Laura Pitt, Tyrone Soumpasis, Ilias
Abstract	BackgroundIt is a common medical practice to characterise an infection based on the causative agent and to adopt therapeutic and prevention strategies targeting the agent itself. However, from an epidemiological perspective, exposure to a microbe can be harmless to a host as a result of low-level exposure or due to host immune response, with opportunistic infection only occurring as a result of changes in the host, pathogen, or surrounding environment.MethodsWe have attempted to review systematically the key host, pathogen, and environmental factors that may significantly impact clinical outcomes of exposure to a pathogen, using Pseudomonas aeruginosa eye infection as a case study.Results and discussionExtended contact lens wearing and compromised hygiene may predispose users to microbial keratitis, which can be a severe and vision-threatening infection. P. aeruginosa has a wide array of virulence-associated genes and sensing systems to initiate and maintain cell populations at the corneal surface and beyond. We have adapted the well-known concept of the epidemiological triangle in combination with the classic risk assessment framework (hazard identification, characterisation, and exposure) to develop a conceptual pathway-based model that demonstrates the overlapping relationships between the host, the pathogen, and the environment; and to illustrate the key events in P. aeruginosa eye infection.ConclusionThis strategy differs from traditional approaches that consider potential risk factors in isolation, and hopefully will aid the identification of data and models to inform preventive and therapeutic measures in addition to risk assessment. Furthermore, this may facilitate the identification of knowledge gaps to direct research in areas of greatest impact to avert or mitigate adverse outcomes of infection.
File Format	PDF HTM / HTML
ISSN	20008686
DOI	10.3402/iee.v5.28750
Journal	Infection Ecology & Epidemiology
Volume Number	5
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2015-11-05
Access Restriction	Open
Subject Keyword	Key events model Dose–response Infection Pseudomonas aeruginosa Keratitis Contact
Content Type	Text
Resource Type	Article
Subject	Environmental Science Epidemiology 2300/2301

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A proof-of-concept model for the identification of the key events in the infection process with specific reference to Pseudomonas aeruginosa in corneal infections

Genipin in an Ex Vivo Corneal Model of Bacterial and Fungal Keratitis.

The clinical and cellular basis of contact lens-related corneal infections

Pseudomonas aeruginosa corneal infection associated with disposable contact lens use.

Corneal response to Pseudomonas aeruginosa infection

Effect of Different Antibiotic Chemotherapies on Pseudomonas aeruginosa Infection In Vitro of Primary Human Corneal Fibroblast Cells

Association of Biofilm Formation, Psl Exopolysaccharide Expression, and Clinical Outcomes in Pseudomonas aeruginosa Keratitis: Analysis of Isolates in the Steroids for Corneal Ulcers Trial

Extended Contact Lens Wear Promotes Corneal Norepinephrine Secretion and Pseudomonas aeruginosa Infection in Mice.

Serrated Margins in Pseudomonas aeruginosa Keratitis

A proof-of-concept model for the identification of the key events in the infection process with specific reference to Pseudomonas aeruginosa in corneal infections

Similar Documents

A proof-of-concept model for the identification of the key events in the infection process with specific reference to Pseudomonas aeruginosa in corneal infections

Genipin in an Ex Vivo Corneal Model of Bacterial and Fungal Keratitis.

The clinical and cellular basis of contact lens-related corneal infections

Pseudomonas aeruginosa corneal infection associated with disposable contact lens use.

Corneal response to Pseudomonas aeruginosa infection

Effect of Different Antibiotic Chemotherapies on Pseudomonas aeruginosa Infection In Vitro of Primary Human Corneal Fibroblast Cells

Association of Biofilm Formation, Psl Exopolysaccharide Expression, and Clinical Outcomes in Pseudomonas aeruginosa Keratitis: Analysis of Isolates in the Steroids for Corneal Ulcers Trial

Extended Contact Lens Wear Promotes Corneal Norepinephrine Secretion and Pseudomonas aeruginosa Infection in Mice.

Serrated Margins in Pseudomonas aeruginosa Keratitis

A proof-of-concept model for the identification of the key events in the infection process with specific reference to Pseudomonas aeruginosa in corneal infections