NDLI: Micronutrient intake in relation to all-cause mortality in a prospective Danish cohort

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Micronutrient intake in relation to all-cause mortality in a prospective Danish cohort

Content Provider	Taylor & Francis Online
Author	Overvad, Kim Christensen, Jane Tjønneland, Anne Hansen, Louise Dragsted, LarsO Roswall, Nina Olsen, Anja
Abstract	Background Few studies have considered source-specific micronutrient intake in relation to mortality under the consideration that dietary and supplemental intake could exhibit different effects. Objective To evaluate the association between intake of vitamin C, E, folate, beta-carotene from diet and supplements, and overall mortality. Furthermore, to examine effect modification by smoking, alcohol intake, and BMI and to investigate if the effect of supplement use differs with dietary micronutrient intake. Methods and Material In a prospective cohort study of 55,453 middle-aged Danes, information regarding diet, supplement use, and lifestyle was collected through questionnaires. During follow-up, 6,767 deaths were identified and incidence rate ratios (IRRs) of mortality related to micronutrient intake were calculated using Cox proportional hazards models. Results The present study found no effect of dietary vitamin C, E, folate, or beta-carotene in relation to mortality. In contrast, supplemental folic acid was associated with a significantly increased mortality, whereas no other micronutrient supplement was associated with mortality. Effect modification by smoking and alcohol intake, but not BMI, was suggested in relation to some dietary micronutrients. The effect of supplements did not differ in groups defined by dietary micronutrient intake. Conclusion This study suggests no effect of dietary micronutrients in relation to overall mortality. Supplemental folic acid was found to be associated with increased mortality, but further studies are required. No other supplemental micronutrient was associated with mortality.
File Format	PDF HTM / HTML
ISSN	16546628 1654661X
DOI	10.3402/fnr.v56i0.5466
Journal	Food & Nutrition Research
Volume Number	56
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2012-04-02
Access Restriction	Open
Subject Keyword	Mortality Dietary supplements Micronutrients Prospective cohort study Vitamin C Vitamin E Folate Beta-carotene
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Public Health, Environmental and Occupational Health Food Science

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