NDLI: Long-term non-invasive ventilation reduces readmissions in COPD patients with two or more episodes of acute hypercapnic respiratory failure

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Long-term non-invasive ventilation reduces readmissions in COPD patients with two or more episodes of acute hypercapnic respiratory failure

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Long-term non-invasive ventilation reduces readmissions in COPD patients with two or more episodes of acute hypercapnic respiratory failure

Content Provider	Taylor & Francis Online
Author	Maibom, Sophia Liff Ankjærgaard, Kasper Linde Wilcke, Jon Torgny
Abstract	BackgroundChronic obstructive pulmonary disease (COPD) patients who have had an episode of acute hypercapnic respiratory failure (AHRF) have a large 1-year risk of death or readmission. Acute non-invasive ventilation (NIV) has been shown to be an effective treatment of AHRF; and long-term NIV (LTNIV) has been shown to be an effective treatment of chronic respiratory failure in stable hypercapnic COPD. We investigated the effects of LTNIV in a group of patients with severe, unstable COPD: frequent admissions and multiple previous episodes of AHRF treated with NIV.MethodsWe conducted a retrospective analysis of 20 COPD patients treated with LTNIV after two or more episodes of AHRF during 1 year.ResultsThe mean number of AHRF episodes decreased from 2.44 in the year prior to LTNIV initiation to 0.44 in the year following (p<0.0001). The median number of admissions decreased from 5.19 to 1.88 (p=0.0092). Four patients (20%) died in 1 year. LTNIV tended to reduce arterial CO2. No changes were found in lung function.ConclusionsLTNIV seems effective in reducing recurrent AHRF and readmissions in a highly select group of patients with severe, unstable COPD and frequent AHRF.
File Format	PDF HTM / HTML
ISSN	20018525
DOI	10.3402/ecrj.v3.28303
Journal	European Clinical Respiratory Journal
Volume Number	3
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-03-31
Access Restriction	Open
Subject Keyword	COPD Ventilation Respiratory failure Hypercapnia Exacerbations
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine

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