NDLI: Extracellular matrix protein fibronectin induces matrix metalloproteinases in human prostate adenocarcinoma cells PC-3

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Migration speed and directionality switch of normal epithelial cells after TGF-β1-induced EMT (tEMT) on micro-structured polydimethylsiloxane (PDMS) substrates with variations in stiffness and topographic patterning

Volume: 20 Issue: 2

Extracellular matrix protein fibronectin induces matrix metalloproteinases in human prostate adenocarcinoma cells PC-3

Content Provider	Taylor & Francis Online
Author	Pal, Sekhar Ganguly, Kirat Kumar Chatterjee, Amitava
Abstract	Studies on interaction of tumor cells with ECM components showed increased extracellular protease activity mediated by the family of matrix metalloproteinases (MMPs). Here we studied the effect of human prostate adenocarcinoma PC-3 cells–fibronectin (FN) interaction on MMPs and the underlying signaling pathways. Culturing of PC-3 cells on FN-coated surface upregulated MMP-9 and MMP-1. This response is abrogated by the blockade of α5 integrin. siRNA and inhibitor studies indicate possible involvement of phosphatidyl-inositol-3-kinase (PI-3K), focal adhesion kinase (FAK) and nuclear factor-kappaB (NF-κB) in FN-induced upregulation of MMPs. FN treatment also enhanced phosphorylation of FAK, PI3K, protein kinase B (PKB or Akt), nuclear translocation of NF-κB, surface expression of CD-44, and cell migration. Our findings indicate that, binding of PC-3 cells to FN, possibly via α5β1 integrin, induces signaling involving FAK, PI-3K, Akt, NF-κB followed by upregulation of MMP-9 and MMP-1. CD-44 may have role in modulating MMP-9 activity.
Starting Page	105
Ending Page	114
Page Count	10
File Format	PDF HTM / HTML
ISSN	15419061 15435180
DOI	10.3109/15419061.2013.833193
Journal	Cell Communication & Adhesion
Volume Number	20
Issue Number	5
Language	English
Publisher	Taylor & Francis
Publisher Date	2013-10-04
Access Restriction	Open
Subject Keyword	PC-3 Signaling ECM Fibronectin Integrin MMP
Content Type	Text
Resource Type	Article
Subject	Cell Biology Clinical Biochemistry

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