NDLI: Aloin: A natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities

Content Provider	Taylor & Francis Online
Author	Esmat, Amr Y. Khalil, Sally A. Said, Mahmoud M.
Abstract	Context: The antitumor activity of aloin, the active anthraquinone of Aloe juice, against different murine and human tumors has been reported.Objective: In the present study, the impact of repeated aloin treatment at its maximum tolerated dose on serum levels of lipid profile, some elements, iron status and kidney function, compared with doxorubicin (a cardiotoxic anthracycline and inhibitor of erythropoiesis), was assessed.Materials and methods: Rats were treated with a single dose of doxorubicin (30 mg/kg body weight, intraperitoneal) or aloin (50 mg/kg body weight, intramuscular) twice weekly over 2 weeks.Results: Acute doxorubicin treatment elevated serum levels of triacylglycerols (59.90%), total cholesterol (42.29%), cholesteryl esters (54.75%), low density lipoprotein–cholesterol (230.16%), very low density lipoprotein–cholesterol (56.42%), urea (287.53%), and creatinine (85.38%), whereas serum high density lipoprotein–cholesterol, sodium, and calcium levels were reduced (44.61, 9.61, and 9.76%, respectively), as compared with controls. In contrast, aloin treatment showed insignificant changes in all the aforementioned parameters. Both doxorubicin and aloin induced erythropoiesis impairment demonstrated by a reduction in blood hemoglobin concentration. While aloin treatment elevated serum iron level (30.28%), doxorubicin treatment reduced serum levels of iron (51.47%) and percent transferrin saturation (55.21%), and in contrast, increased serum total iron binding capacity (34.85%). The chelating affinities of iron-aloin and -doxorubicin complexes, which contain bidentate iron-binding moieties, have been shown in the infrared spectra.Discussion and conclusion: The non-cardiotoxic effect of aloin treatment was due to its non-atherogenic and iron-chelating activities, which might also contribute in part to its anti-proliferative activity.
Starting Page	138
Ending Page	146
Page Count	9
File Format	PDF HTM / HTML
ISSN	13880209 17445116
DOI	10.3109/13880209.2014.912239
Journal	Pharmaceutical Biology
Volume Number	53
Issue Number	1
Language	English
Publisher	Informa Healthcare
Publisher Date	2014-12-18
Access Restriction	Open
Subject Keyword	Aloin Doxorubicin Electrolytes Iron Infrared analysis Lipid profile
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Hypoglycemic activity of Iraqi Rheum ribes root extract

Anthraquinone Glycoside Aloin Induces Osteogenic Initiation of MC3T3-E1 Cells: Involvement of MAPK Mediated Wnt and Bmp Signaling

Anthraquinone Glycoside Aloin Induces Osteogenic Initiation of MC3T3-E1 Cells: Involvement of MAPK Mediated Wnt and Bmp Signaling.

Immunomodulation and antitumor activities of Aged Garlic Extract.

Molecular-Targeted Antitumor Agents 19

Plumbagin, A Plant Naphthoquinone with Antitumor and Radiomodifying Properties

Antioxidant and Antitumor Promoting Activities of the Flavonoids from Hedychium thyrsiforme

Anti-inflammatory, free radical-scavenging, and metal-chelating activities of Malva parviflora

Melampodium leucanthum, a Source of CytotoxicSesquiterpenes with Antimitotic Activities

Aloin: A natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities

Similar Documents

Hypoglycemic activity of Iraqi Rheum ribes root extract

Anthraquinone Glycoside Aloin Induces Osteogenic Initiation of MC3T3-E1 Cells: Involvement of MAPK Mediated Wnt and Bmp Signaling

Anthraquinone Glycoside Aloin Induces Osteogenic Initiation of MC3T3-E1 Cells: Involvement of MAPK Mediated Wnt and Bmp Signaling.

Immunomodulation and antitumor activities of Aged Garlic Extract.

Molecular-Targeted Antitumor Agents 19

Plumbagin, A Plant Naphthoquinone with Antitumor and Radiomodifying Properties

Antioxidant and Antitumor Promoting Activities of the Flavonoids from Hedychium thyrsiforme

Anti-inflammatory, free radical-scavenging, and metal-chelating activities of Malva parviflora

Melampodium leucanthum, a Source of CytotoxicSesquiterpenes with Antimitotic Activities

Aloin: A natural antitumor anthraquinone glycoside with iron chelating and non-atherogenic activities