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| Content Provider | Taylor & Francis Online |
|---|---|
| Author | Arvindekar, Akalpita U. Kulkarni, Chaitanya R. Patil, Swapnil B. Joglekar, Madhav M. |
| Abstract | Context: Santalum album Linn (Santalaceae), commonly known as Sandalwood is used traditionally for its antihyperlipidemic and diuretic activity.Objective: This study investigated the antihyperglycemic and antihyperlipidemic effect of long-term oral administration of the Santalum album pet ether fraction in streptozotocin-induced diabetic rats.Materials and methods: Diabetes was induced by a single intraperitoneal injection of streptozotocin at 70 mg/kg body weight. Rats were treated with Santalum album pet ether fraction orally at a dose of 10 µg/kg body weight twice daily for 60 days. Metformin (30 mg/kg body weight) was used as positive control. Lipid profile and glycated hemoglobin were estimated. HPLC profiling of Santalum album pet ether fraction was carried out.Results and discussion: Treatment of diabetic rats for 60 days demonstrated reduction in blood glucose level by 140 mg/dl. Metformin treated group showed a decrease in blood glucose by 70 mg/dl, as against an increase in diabetic control group by 125 mg/dl. Total cholesterol (TC), low density lipoprotein (LDL) and triglyceride (TG) levels were decreased by 22, 31 and 44%, respectively, in treated diabetic rats whereas, cardioprotective, high density lipoprotein (HDL) increased by 46%. In case of metformin, the values were 11, 29 and 15% respectively, while HDL increased by 7%. Significant improvement in atherogenic index from 267 to 139% was observed in treated rats.Conclusion: Santalum album pet ether fraction has potential antihyperlipidemic activity that can help in overcoming insulin resistance. |
| Starting Page | 360 |
| Ending Page | 365 |
| Page Count | 6 |
| File Format | PDF HTM / HTML |
| ISSN | 13880209 17445116 |
| DOI | 10.3109/13880209.2011.604677 |
| Journal | Pharmaceutical Biology |
| Volume Number | 50 |
| Issue Number | 3 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2012-02-10 |
| Access Restriction | Open |
| Subject Keyword | Antidiabetic Metformin Atherogenic index |
| Content Type | Text |
| Resource Type | Article |
| Subject | Drug Discovery Pharmacology Molecular Medicine Complementary and Alternative Medicine Pharmaceutical Science |
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