NDLI: Quercetin ameliorates methotrexate-induced renal damage, apoptosis and oxidative stress in rats

Content Provider	Taylor & Francis Online
Author	Erboga, Zeynep Fidanol Erboga, Mustafa Aktas, Cevat Donmez, Yeliz Bozdemir Gurel, Ahmet
Abstract	Background: In the present study, the protective and therapeutic effects of quercetin (QE) on renal injury induced by methotrexate (MTX) have been examined. Materials and methods: A total of 24 male rats were divided into the following three groups: control group, MTX group, and MTX + QE group. Rats in MTX group received 20 mg/kg of single dose of MTX, while those in MTX + QE group received 20 mg/kg of single dose MTX, in addition to 15 mg/kg of QE administered 30 min prior to MTX and in the following 5-day period as a single daily dose. At the end of the experimental period, renal tissues were removed for histopathological and biochemical assessments. Results: Light microscopic examination showed a disruption of the renal structure in rats in MTX group in the form of tubular degeneration and dilation, with shedding of the tubular epithelial cells into the lumen. QE treatment was associated with less marked degenerative changes, with a similar histological appearance to that of controls. Furthermore, QE treatment resulted in decreased the number of apoptotic cells. Biochemical assessments showed significantly higher malondialdehyde (MDA) levels in MTX group as compared to control and MTX + QE groups. superoxide dismutase (SOD), glutathione peroxidase (GSH-Px), and catalase (CAT) levels showed a significant decrease in MTX group as compared to controls. However, QE significantly suppressed MDA level, compensated deficits in the anti-oxidant defenses [reduced SOD, GSH-Px, and CAT levels] in kidney tissue resulted from MTX administration. Conclusions: In conclusion, renal toxic effects of MTX may be alleviated by QE.
Starting Page	1492
Ending Page	1497
Page Count	6
File Format	PDF HTM / HTML
ISSN	0886022X 15256049
DOI	10.3109/0886022X.2015.1074521
Journal	Renal Failure
Volume Number	37
Issue Number	9
Language	English
Publisher	Informa Healthcare
Publisher Date	2015-08-31
Access Restriction	Open
Subject Keyword	Apoptosis Methotrexate Nephrotoxicity Oxidative stress Quercetin
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine Nephrology

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