NDLI: De-escalation of radiotherapy for the treatment of HPV-associated head and neck cancer: A case report and a word of caution

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Volume 1, 2016

De-escalation of radiotherapy for the treatment of HPV-associated head and neck cancer: A case report and a word of caution

Content Provider	Taylor & Francis Online
Author	Harvey, Mark E. Kameh, Darian S. Rao, Nikhil G. Ho, Henry Haughey, Bruce Magnuson, Scott Mekhail, Tarek Zehngebot, Lee Akhtar, Adnan Keller, Andrew
Abstract	Background: It has been noted that HPV associated head and neck cancers have an increased responsiveness to radiotherapy. For this reason, strategies at de-escalation are currently being prospectively evaluated.Methods: We report a case of a 58-year-old male who presented with a right neck mass and was diagnosed with HPV associated, p16 positive, cT2N2bM0 tonsillar squamous cell carcinoma. The patient unintentionally received reduced doses of radiation and systemic therapy due to inability to tolerate treatment.Results: The patient was found to have no evidence of disease on 4-month follow-up PET scan and clinical exam. However, several months later, he developed disease recurrence and ultimately required surgical salvage.Conclusions: Until mature results from prospective phase 3 clinical trials are available, we recommend caution in the de-intensification of therapy particularly as current therapy achieves high rates of long term disease control.
Starting Page	29
Ending Page	33
Page Count	5
File Format	PDF HTM / HTML
ISSN	23772484
DOI	10.1080/23772484.2017.1292399
Journal	Acta Oto-Laryngologica Case Reports
Volume Number	2
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2017-02-19
Access Restriction	Open
Subject Keyword	HPV Oropharyngeal carcinoma Radiotherapy De-escalation Head and neck cancer
Content Type	Text

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