NDLI: Impact of frequency of denture cleaning on microbial and clinical parameters – a bench to chairside approach

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Volume 11, 2019

Volume: 11 Issue: 1

Xylitol and sorbitol effects on the microbiome of saliva and plaque

Preliminary study of the oral mycobiome of children with and without dental caries

Role of OmpA1 and OmpA2 in Aggregatibacter actinomycetemcomitans and Aggregatibacter aphrophilus serum resistance

Do the oral Staphylococcus aureus strains from denture wearers have a greater pathogenicity potential?

Impact of frequency of denture cleaning on microbial and clinical parameters – a bench to chairside approach

Regulation of gingival epithelial cytokine response by bacterial cyclic dinucleotides

Antimicrobial peptide GH12 targets Streptococcus mutans to arrest caries development in rats

Aggregatibacter actinomycetemcomitans LPS binds human interleukin-8

Determination of copy number and circularization ratio of Tn916-Tn1545 family of conjugative transposons in oral streptococci by droplet digital PCR

Microcosm biofilms cultured from different oral niches in periodontitis patients

Volume 10, 2018

Impact of frequency of denture cleaning on microbial and clinical parameters – a bench to chairside approach

Content Provider	Taylor & Francis Online
Author	O’Donnell, Lindsay Bradshaw, David Sherry, Leighann Culshaw, Shauna Jose, Anto Bagg, Jeremy MacInnes, Andrew Cross, Laura McKenzie, Debbie Brown, Clare Pereira, Paola Gomez Varghese, Roshan Sanyal, Susmita Czesnikiewicz-Guzik, Marta Robertson, Douglas Ramage, Gordon
Abstract	Objective: Robust scientific and clinical evidence of how to appropriately manage denture plaque is lacking. This two-part study (i) developed an in vitro model of denture plaque removal, and (ii) assessed effectiveness of these approaches in a randomised clinical trial.Method: (i) a complex denture plaque model was developed using the dominant microbial genera from a recent microbiome analyses. Biofilms formed on polymethylmethacrylate were brushed daily with a wet toothbrush, then either treated daily for 5 days or only on Days 1 and 5 with Polident® denture cleanser tablets (3 min soaking). Quantitative and qualitative microbiological assessments were performed. (ii), an examiner-blind, randomised, crossover study of complete maxillary denture wearers was performed (n = 19). Either once-daily for 7 days or on Day 7 only, participants soaked dentures for 15 min using Corega® denture cleansing tables, then brushed. Denture plaque microbiological assessment used sterilized filter paper discs.Results: The in vitro model showed daily cleaning with denture cleanser plus brushing significantly reduced microbial numbers compared to intermittent denture cleaning with daily brushing (p < 0.001). The clinical component of the study showed a statistically significant reduction in denture plaque microbial numbers in favour of daily versus weekly treatment (aerobic bacteria p = 0.0144). Both in vitro and in vivo studies showed that denture plaque biofilm composition were affected by different treatment arms.Conclusions: This study demonstrated that daily denture cleansing regimens are superior to intermittent denture cleansing, and that cleansing regimens can induce denture plaque compositional changes. Clinicaltrials.gov registration: NCT02780661.
File Format	PDF HTM / HTML
ISSN	20002297
DOI	10.1080/20002297.2018.1538437
Journal	Journal of Oral Microbiology
Volume Number	11
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2018-10-29
Access Restriction	Open
Subject Keyword	Denture Plaque Microbiology Denture cleansing Oral microbiome Antimicrobials
Content Type	Text
Resource Type	Article
Subject	Microbiology (medical) Dentistry Infectious Diseases 3500/3501

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