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| Content Provider | Taylor & Francis Online |
|---|---|
| Author | Dewhirst, Floyd E. Tanner, Anne Cr Frias-Lopez, Jorge Tavares, Mary A. Kressirer, Christine A. Chen, Tsute Harriman, Kristie Lake |
| Abstract | Background: Dental caries results from a dysbiosis of tooth-associated biofilms and frequently extends through enamel into dentin which has a different structure and composition.Objective: To evaluate the metatranscriptome of caries to determine the metabolic potential of caries communities compared with health.Design: Samples from children, caries-free (CF: n = 4) or with coronal (CC: n = 5) or dentin (DC: n = 5) caries were examined for gene expression potential. Functional profiling was performed using HUMAnN2 (HMP Unified Metabolic Analysis Network).Results: There was increased gene expression diversity in DC compared with CC and CF. Genes in CF included alcohol dehydrogenase from Neisseria sicca, methylenetetrahydrofolate reductase from Streptococcus sanguinis and choline kinase from streptococci. Genes in CC mapped mainly to Streptococcus mutans. Arginine deiminase in DC mapped to S. sanguinis and Actinomyces naeslundii. Glycerol kinase genes mapped to S. sanguinis in all groups whereas glycerol kinase in DC were from Rothia, Prevotella and streptococci. Uracil-DNA glycosylase in DC mapped to Prevotella denticola and Actinomyces. Repressor LexA in DC mapped to Scardovia wiggsiae, Dialister invisus and Veillonella parvula.Conclusions: Functional profiling revealed enzyme activities in both caries and caries-free communities and clarified marked differences between coronal and dentin caries in bacterial composition and potential gene expression. |
| File Format | PDF HTM / HTML |
| ISSN | 20002297 |
| DOI | 10.1080/20002297.2018.1495976 |
| Journal | Journal of Oral Microbiology |
| Volume Number | 10 |
| Issue Number | 1 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2018-07-16 |
| Access Restriction | Open |
| Subject Keyword | Metatranscriptome Microbiota Dental plaque Caries Children |
| Content Type | Text |
| Resource Type | Article |
| Subject | Microbiology (medical) Dentistry Infectious Diseases 3500/3501 |
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