NDLI: Changes in the inflammatory and oxidative stress markers during a single hemodialysis session in patients with chronic kidney disease

Content Provider	Taylor & Francis Online
Author	Devi, N. Harini Lakshmi, B. Sangeetha Rao, P. V. L. N. Srinivasa Kumar, V. Siva Suchitra, M. M.
Abstract	Background: Cardiovascular disease (CVD) is a common cause of morbidity and mortality in end-stage renal disease (ESRD) patients on hemodialysis (HD) among whom it is 5–20 times higher than in the general population. Some of the nontraditional risk factors such as oxidative stress and inflammation are related to the progress of CVD in HD patients. Several, but not all studies, reported that inflammatory and oxidative stress markers are increased during a single session of HD, mimicking changes that occur during acute immune activation. This study was taken up to evaluate the changes in the inflammatory and oxidative stress markers during a single HD session in patients with chronic kidney disease.Methods: Twenty-five ESRD patients on maintenance HD and 25 controls were included in the study. Blood samples were obtained from the patients before starting of hemodialysis (pre-HD) and after completion of hemodialysis (post-HD). The changes in serum Pentraxin-3, hs-CRP, malondialdehyde (MDA) and ferric reducing ability of plasma (FRAP) levels were measured in pre- and post-HD ESRD patients and compared with healthy control group.Results: This study found increased levels of Pentraxin-3, hs-CRP, MDA, and decreased level of FRAP in HD patients compared to controls.Conclusions: Hemodialysis procedure contributes to inflammation and oxidative stress.
Starting Page	534
Ending Page	540
Page Count	7
File Format	PDF HTM / HTML
ISSN	0886022X 15256049
DOI	10.1080/0886022X.2018.1487857
Journal	Renal Failure
Volume Number	40
Issue Number	1
Language	English
Publisher	Taylor & Francis
Publisher Date	2018-10-02
Access Restriction	Open
Subject Keyword	Cardiovascular disease Hemodialysis Inflammation Pentraxin-3 Oxidative stress
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine Nephrology

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