NDLI: Positive Correlation of CRP and Fibrinogen Levels as Cardiovascular Risk Factors in Early Stage of Continuous Ambulatory Peritoneal Dialysis Patients

Content Provider	Taylor & Francis Online
Author	Pocan, Bekir Borazan, Ali Ucar, Edip Kadayifci, Sinan Demircan, Nejat Kuvandik, Guven Ozer, Cahit Ilikhan, Sevil Tekin, Ishak Ozel
Abstract	We aimed to study the relationship between the C-reactive protein (CRP), albumin, and fibrinogen as cardiovascular risk factors in continuous ambulatory peritoneal dialysis (CAPD) patients, in the early stage of their therapy. The study included 21 CAPD patients as the study group (SG) and age- and sex-matched 21 healthy patients as the control group (CG). History and physical exam data were obtained for all cases, and demographic baseline characteristics were taken. Twelve-hour fasting serum levels of glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglyceride, total protein, albumin, hemoglobin, CRP, and fibrinogen were obtained.There was no statistically significant difference between the SG and CG in baseline characteristics, including age, sex, body mass index (BMI), smoking, and family history of cardiovascular disease. However, diabetes mellitus (DM) and hypertension (HTN) were significantly more common among the study group. The average total protein, albumin, and hemoglobin levels were significantly lower, and the CRP and fibrinogen levels were significantly higher (p < 0.001) in the SG. A positive correlation was seen (r = 0.443, p < 0.05) among CRP and fibrinogen levels in SG. There was no correlation among the other parameters in SG. For CG, there was no correlation seen for any studied parameters. When patients with and without cardiovascular disease (CVD) were compared, no correlation was seen between CRP and other parameters. A positive correlation of CRP and fibrinogen levels as cardiovascular risk factors was shown in early stage of CAPD patients. The CAPD patients with elevated levels of CRP and fibrinogen should receive close follow-up for cardiovascular disease prevention.
Starting Page	219
Ending Page	225
Page Count	7
File Format	PDF HTM / HTML
ISSN	0886022X 15256049
DOI	10.1080/08860220701813350
Journal	Renal Failure
Volume Number	30
Issue Number	2
Language	English
Publisher	Taylor & Francis
Publisher Date	2009-07-07
Access Restriction	Open
Subject Keyword	Chronic renal disease Coronary artery disease Anticardiolipin antibodies Echocardiography Coronary angiography
Content Type	Text
Resource Type	Article
Subject	Critical Care and Intensive Care Medicine Nephrology

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