NDLI: Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein

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Blocking transmission of Middle East respiratory syndrome coronavirus (MERS-CoV) in llamas by vaccination with a recombinant spike protein

Content Provider	Taylor & Francis Online
Author	Bosch, Berend-jan Dieren, Brenda Van Bensaid, Albert Nisreen, M. A. Okba Bart, L. Haagmans Te, Nigeer Vergara-alert, Júlia Rodon, Jordi Segalés, Joaquim
Abstract	The ongoing Middle East respiratory syndrome coronavirus (MERS-CoV) outbreaks pose a worldwide public health threat. Blocking MERS-CoV zoonotic transmission from dromedary camels, the animal reservoir, could potentially reduce the number of primary human cases. Here we report MERS-CoV transmission from experimentally infected llamas to naïve animals. Directly inoculated llamas shed virus for at least 6 days and could infect all in-contact naïve animals 4–5 days after exposure. With the aim to block virus transmission, we examined the efficacy of a recombinant spike S1-protein vaccine. In contrast to naïve animals, in-contact vaccinated llamas did not shed infectious virus upon exposure to directly inoculated llamas, consistent with the induction of strong virus neutralizing antibody responses. Our data provide further evidence that vaccination of the reservoir host may impede MERS-CoV zoonotic transmission to humans.
ISSN	22221751
Journal	Emerging Microbes & Infections
DOI	10.1080/22221751.2019.1685912
Language	English
Publisher	Taylor & Francis
Publisher Date	2019-11-12
Access Restriction	Open
Subject Keyword	Animal model Middle East respiratory syndrome coronavirus llama S1-protein-based vaccine virus transmission MERS-CoV
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Virology Drug Discovery Parasitology Immunology Microbiology Epidemiology

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