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| Content Provider | Springer Nature : SpringerOpen |
|---|---|
| Author | Akçiçek, Esra Durhan, Gamze Düzgün, Selin Ardalı Kurtulan, Olcay Akpınar, Meltem Gülsün Demirkazık, Figen Arıyürek, Orhan Macit |
| Abstract | Various processes, including benign or malignant (mostly metastasis) processes, contribute to the occurrence of multiple pulmonary nodules. For differential diagnosis, metastasis must be excluded as an etiological factor in patients who have multiple pulmonary nodules with a known primary malignancy. However, differential diagnosis of multiple pulmonary nodules caused by benign diseases and malignant processes is challenging. Multiple pulmonary nodules resulting from metastasis may mimic those resulting from infections, inflammatory processes, and rare benign diseases. Some rare diseases, such as pulmonary sclerosing pneumocytoma and pulmonary epithelioid hemangioendothelioma, or common diseases with a rare presentation of multiple nodules must be considered in the differential diagnosis of metastasis. In addition to the clinical and laboratory findings, radiological features are crucial for differential diagnosis. The size, density, location, and border characteristics (well-defined or poorly defined) of pulmonary nodules, as well as their internal structure (solid, subsolid, or ground glass nodule), growth rate during follow-up, and associated pulmonary and extrapulmonary findings are important for differential diagnosis along with clinical and laboratory data. This article summarizes the general features and imaging findings of these diseases, which less frequently present with multiple pulmonary nodules, and the clues that can be used to distinguish these diseases from metastasis. The radiological features, clinical findings, and temporal changes during follow-up are important in distinguishing non-metastatic causes of multiple pulmonary nodules from metastatic causes and guiding diagnosis and early treatment, especially in patients with primary malignancy. |
| Related Links | https://insightsimaging.springeropen.com/counter/pdf/10.1186/s13244-024-01856-9 |
| Ending Page | 16 |
| Page Count | 16 |
| Starting Page | 1 |
| ISSN | 18694101 |
| DOI | 10.1186/s13244-024-01856-9 |
| Journal | Insights into Imaging |
| Issue Number | 1 |
| Volume Number | 15 |
| Language | English |
| Publisher | SpringerOpen |
| Publisher Date | 2024-11-29 |
| Access Restriction | Open |
| Subject Keyword | Multiple pulmonary nodules Metastasis Computed tomography Diagnostic imaging |
| Content Type | Text |
| Resource Type | Article |
| Subject | Radiology, Nuclear Medicine and Imaging |
| Aim | Insights into Imaging is a peer-reviewed, online gold open access journal published under the brand SpringerOpen. Owned by the European Society of Radiology (ESR), Insights into Imaging accepts original articles, educational and critical review articles as well as position and recommendation papers from leading societies and institutions. Through critical thinking and re-thinking, the authors should provide an insight into how radiology is currently practised and analyse whether it needs to be re-shaped. Insights into Imaging is the official journal of the following organisations: European Society of Cardiovascular Radiology (ESCR) European Society of Gastrointestinal and Abdominal Radiology (ESGAR) European Society of Head and Neck Radiology (ESHNR) European Society of Neuroradiology (ESNR) European Society of Oncologic Imaging (ESOI) European Society of Musculoskeletal Radiology (ESSR) European Society of Thoracic Imaging (ESTI) European Society of Urogenital Radiology (ESUR) European Society of Breast Imaging (EUSOBI) European Society of Medical Imaging Informatics (EuSoMII) |
| Journal Impact Factor | 4.5/2024 |
| 5-Year Journal Impact Factor | 5.3/2024 |
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