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  1. Stem Cell Research & Therapy
  2. Volume 2
  3. Issue 1
  4. The fate of proliferating cells in the injured adult spinal cord
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Volume 16
Volume 15
Volume 14
Volume 13
Volume 12
Volume 11
Volume 10
Volume 9
Volume 8
Volume 7
Volume 6
Volume 5
Volume 4
Volume 3
Volume 2
Issue 6
Issue 5
Issue 4
Issue 3
Issue 2
Issue 1
Stem cells in veterinary medicine
Fibroblasts derived from human embryonic stem cells direct development and repair of 3D human skin equivalents
Mesenchymal chondroprogenitor cell origin and therapeutic potential
The fate of proliferating cells in the injured adult spinal cord
Transcriptional regulation of haematopoietic transcription factors
Cell fate conversion by mRNA
Engineering a stem cell house into a home
Fetal derived embryonic-like stem cells improve healing in a large animal flexor tendonitis model
Characterization of the radioresponse of human apical papilla-derived cells
From fibroblast cells to cardiomyocytes: direct lineage reprogramming
Volume 1

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The fate of proliferating cells in the injured adult spinal cord

Content Provider Springer Nature : BioMed Central
Author McTigue, Dana M Sahinkaya, FRezan
Abstract Endogenous cell proliferation and gliogenesis have been extensively documented in spinal cord injury, particularly in terms of proliferating oligodendrocyte progenitor cells. Despite the characterization of different proliferating cell types in the intact and injured spinal cord, the exact sources of new glial cells have remained elusive. Most studies on cell fate within the spinal cord have focused on following the progeny of one specific population of dividing cells, thus making it difficult to understand the relative contributions of each mitotic cell population to the formation of new glia after spinal cord injury. A recent study from the Frisen laboratory is the first to quantitatively and qualitatively characterize the response of ependymal cells, oligodendrocyte progenitors, and astrocytes in parallel by using transgenic reporter mice corresponding to each cell type. The investigators characterize the distribution and phenotype of progeny, along with the quantitative contributions of each progenitor type to newly formed cells. Their findings provide valuable insight into the endogenous cell replacement response to spinal cord injury, thus paving the way for advances in modulating specific populations of progenitor cells with the goal of promoting structural and functional recovery after spinal cord injury.
Related Links https://stemcellres.biomedcentral.com/counter/pdf/10.1186/scrt48.pdf
Ending Page 2
Page Count 2
Starting Page 1
File Format HTM / HTML
ISSN 17576512
DOI 10.1186/scrt48
Journal Stem Cell Research & Therapy
Issue Number 1
Volume Number 2
Language English
Publisher BioMed Central
Publisher Date 2011-02-14
Access Restriction Open
Subject Keyword Stem Cells Cell Biology Regenerative Medicine Tissue Engineering Biomedical Engineering and Bioengineering Spinal Cord Spinal Cord Injury Ependymal Cell Central Canal Oligodendrocyte Progenitor Cell Regenerative Medicine/Tissue Engineering
Content Type Text
Subject Cell Biology Medicine Biochemistry, Genetics and Molecular Biology Molecular Medicine
Journal Impact Factor 7.1/2023
5-Year Journal Impact Factor 7.9/2023
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