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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Or, Chris Heier, Jeffrey S. Boyer, David Brown, David Shah, Sumit Alibhai, Agha Yasin Fujimoto, James G. Waheed, Nadia |
| Abstract | Background To investigate whether neovascularization may arise and be detectable in drusen, as reported in histopathologic studies, by OCTA prior to developing exudation and to assess its prevalence in a cohort of patients with intermediate AMD. Methods Retrospective cross-sectional study of 128 patients with intermediate AMD recruited as part of a separate ongoing clinical trial conducted at multiple large tertiary referral retina clinics. One hundred and twenty-eight consecutive patients with exudative AMD in one eye and intermediate non-exudative AMD in the fellow eye were enrolled and analyzed between September 2015 and March 2017. Results SD-OCTA identified vascularization within drusen in 7 of 128 eyes, for a prevalence of 5.5%. A total of 12 instances of vascularized drusen were noted. Out of the 12 vascularized drusen noted, 7 were located in the parafoveal region or subfoveal region and 5 was in the extrafoveal region. 9 of 12 instances of vascularized drusen exhibited a uniform sub-RPE hyperreflectivity, whilst 3 of 12 exhibited more heterogenous reflectivity. In all 12 instances, FA images failed to identify the neovascular nature of vascularized drusen. Conclusions Our results demonstrate the utility of SD-OCTA for the diagnosis of vascularized drusen in patients with intermediate non-exudative AMD. Longitudinal studies are needed to delineate the evolution and conversion risk of these lesions over time, which can be of substantial clinical relevance. |
| Related Links | https://journalretinavitreous.biomedcentral.com/counter/pdf/10.1186/s40942-019-0187-6.pdf |
| Ending Page | 6 |
| Page Count | 6 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 20569920 |
| DOI | 10.1186/s40942-019-0187-6 |
| Journal | International Journal of Retina and Vitreous |
| Issue Number | 1 |
| Volume Number | 5 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2019-08-20 |
| Access Restriction | Open |
| Subject Keyword | Ophthalmology Age-related macular degeneration Retina Optical coherence tomography Optical coherence tomography angiography Vascularized drusen Retinal imaging |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ophthalmology |
| Journal Impact Factor | 2/2023 2.0/2023 |
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