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| Content Provider | Springer Nature : BioMed Central |
|---|---|
| Author | Zhang, Xian-Bin Fan, Yi-Bao Jing, Rui Getu, Mikiyas Amare Chen, Wan-Ying Zhang, Wei Dong, Hong-Xia Dakal, Tikam Chand Hayat, Akhtar Cai, Hua-Jun Ashrafizadeh, Milad Abd El-Aty, A. M. Hacimuftuoglu, Ahmet Liu, Peng Li, Tian-Feng Sethi, Gautam Ahn, Kwang Seok Ertas, Yavuz Nuri Chen, Min-Jiang Ji, Jian-Song Ma, Li Gong, Peng |
| Abstract | Neuroendocrine neoplasms (NENs) are highly heterogeneous and potentially malignant tumors arising from secretory cells of the neuroendocrine system. Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) are the most common subtype of NENs. Historically, GEP-NENs have been regarded as infrequent and slow-growing malignancies; however, recent data have demonstrated that the worldwide prevalence and incidence of GEP-NENs have increased exponentially over the last three decades. In addition, an increasing number of studies have proven that GEP-NENs result in a limited life expectancy. These findings suggested that the natural biology of GEP-NENs is more aggressive than commonly assumed. Therefore, there is an urgent need for advanced researches focusing on the diagnosis and management of patients with GEP-NENs. In this review, we have summarized the limitations and recent advancements in our comprehension of the epidemiology, clinical presentations, pathology, molecular biology, diagnosis, and treatment of GEP-NETs to identify factors contributing to delays in diagnosis and timely treatment of these patients. |
| Related Links | https://mmrjournal.biomedcentral.com/counter/pdf/10.1186/s40779-024-00535-6.pdf |
| Ending Page | 20 |
| Page Count | 20 |
| Starting Page | 1 |
| File Format | HTM / HTML |
| ISSN | 20549369 |
| DOI | 10.1186/s40779-024-00535-6 |
| Journal | Military Medical Research |
| Issue Number | 1 |
| Volume Number | 11 |
| Language | English |
| Publisher | BioMed Central |
| Publisher Date | 2024-06-04 |
| Access Restriction | Open |
| Subject Keyword | Emergency Medicine Gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) Neuroendocrine neoplasms (NENs) Diagnosis Chemotherapy Immunotherapy |
| Content Type | Text |
| Resource Type | Review |
| Subject | Medicine |
| Journal Impact Factor | 16.7/2023 |
| 5-Year Journal Impact Factor | 14.8/2023 |
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