NDLI: Corneal transplantation outcomes after the extrusion of an intrastromal keratoprosthesis: a pilot study

Content Provider	Springer Nature : BioMed Central
Author	Fariselli, Chiara Toprak, Ibrahim Al-Shymali, Olena Alio del Barrio, Jorge L. Alio, Jorge L.
Abstract	This short report includes 5 eyes of 5 patients (mean age 63.2 ± 12 years) who underwent a tectonic keratoplasty [deep anterior lamellar keratoplasty (DALK) or penetrating keratoplasty (PK)] in order to rehabilitate the eye after the extrusion of the non-perforating keratoprosthesis (Kpro) KeraKlear (KeraMed, USA). The non-perforating Kpro was extruded after a mean period of 21.4 ± 21.8 months due to melting. In two cases, the keratoplasty was performed the same day of the non-perforating Kpro removal due to a severe melting, while in the other three cases it was performed one to 3 months later. Two eyes received a DALK, but in 3 eyes a macroscopic Descemet membrane perforation forced the conversion into a PK. The mean follow-up period after the keratoplasty was 16.8 ± 6.6 months. No cases of rejection were recorded. All the 5 eyes achieved “anatomical success” (transparent graft, with no signs of infection or inflammation). Two eyes showed limited “functional success” because the achievement of the best visual potential was prevented by the development of glaucomatous optic atrophy during the follow-up period. In conclusion, this short report presents an unexpected success of a keratoplasty performed with a tectonic purpose after the extrusion of the non-perforating Kpro because the corneal graft remained transparent, without neovascularization or scarring during the follow-up period. This initial evidence shows some encouraging results regarding graft survival rate and the achievement of a useful visual rehabilitation with keratoplasty after a non-perforating Kpro failure instead of repeating the Kpro implantation.
Related Links	https://eandv.biomedcentral.com/counter/pdf/10.1186/s40662-020-00193-4.pdf
Ending Page	5
Page Count	5
Starting Page	1
File Format	HTM / HTML
ISSN	23260254
DOI	10.1186/s40662-020-00193-4
Journal	Eye and Vision
Issue Number	1
Volume Number	7
Language	English
Publisher	BioMed Central
Publisher Date	2020-05-08
Access Restriction	Open
Subject Keyword	Ophthalmology Keratoprosthesis Extrusion Keratoplasty Corneal transplantation
Content Type	Text
Subject	Ophthalmology Health Professions
Journal Impact Factor	4.2/2023
5-Year Journal Impact Factor	4.1/2023

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